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Esophagus. Nir Hus MD, PhD. ABSITE Review Department of Surgery Mount Sinai Medical Center. Esophagus: Anatomy. Esophagus: Anatomy. Esophagus: Anatomy. Esophageal Studies. Anatomic Esophagogram CT-Scan Endoscopy(Biopsy/Ultrasound) Functional Esophageal manometry 24 hour pH probe.
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Esophagus Nir Hus MD, PhD. ABSITE Review Department of Surgery Mount Sinai Medical Center Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Esophagus: Anatomy Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Esophagus: Anatomy Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Esophagus: Anatomy Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Esophageal Studies • Anatomic • Esophagogram • CT-Scan • Endoscopy(Biopsy/Ultrasound) • Functional • Esophageal manometry • 24 hour pH probe Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Esophagus:Physiology Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Esophageal Manometry Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Esophageal Manometry: Swallowing Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Characteristics of Lower Esophageal Sphincter • Intramural pressure • Length of LES • Abdominal length LES Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Manometry LES: Pressure/Length Relationship Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
24-Hour pH Monitoring Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Esophageal Motility Disorders • Esophageal Diverticula • Zenker’s (pulsion) • Epiphrenic • Traction (pulsion) • Functional Disorders • Achalasia • Diffuse esophageal spasm • Nutcracker esophagus Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Zenker’s Diverticulum • Dysphagia • Regurgitation undigested food • Aspiration • Unyielding cricopharingeous • Dx: barium swallow • No endoscopy • Tx: diverticulectomy/myotomy • Left cervical incision Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Achalasia • Dysphagia and regurgitation undigested food • Substernal/epigastric pain • Diagnosis and work-up: CXR, UGIS • endoscopy/bx: esophagitis, r/o Ca • Manometry: • aperistalsis • incomplete relaxation of LES • High resting pressure LES (>30 mmHg) Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Achalasia Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Achalasia: Treatment • Esophageal dilations, success rate: 70% • Botulinum toxin injections: short lived • Surgery: Heller myotomy, success rate: 95% • Indications: • children • vigorous achalasia • medical failures Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Achalasia: Heller Operation Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Diffuse Esophageal Spasm and Nutcracker Esophagus • Intermittent chest pain and dysphagia • Negative cardiac work-up • Manometry: normal LES, tertiary peristalsis • Treatment: • Medical: reduce stress and precipitating factors • NTG, Isosorbide, Nifedipine • Surgery: Full length myotomy, success rate 65% Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Nutcracker Esophagus Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
GERD • Abnormal exposure of distal esophagus to refluxed gastric juice • Etiology • Mechanically defective LES (60%) • Poor esophageal clearance • Gastric outlet obstruction • Functional delayed gastric emptying • Increased gastric acid secretion • inappropriate relaxation of LES Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
GERD • Symptoms • Substernal/epigastric burning pain • Regurgitation • Effortless emesis • Dysphagia • Flatulence • Atypical symptoms Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
GERD • Complications (20%) • Esophagitis • Stricture • Barrett’s esophagus • Ulceration • Esophageal shortening Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
GERD: Work-up • UGIS and EGD • Manometry: characterizes LES and motility • LES pressure < 6 mm Hg • Overall length < 2 cm • Abdominal length < 1 cm • Esophageal pH testing (sens/specif - 90%) • pH < 4 more than 1 hour and a half/24 hours (6%) • Composite score derived from: total time pH <4, upright time pH <4, supine time pH <4, # episodes, episodes >5 min, longest episode. Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
GERD: Treatment • Medical • Postural alterations • Dietary alterations • Pharmacologic • Surgery • Symptomatic reflux, manometric evidence of incompetent LES, and failure of medical therapy • Development of complications Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Nissen Fundoplication Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Belsey-Mark IV Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Collis Gastroplasty Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Barrett’s Esophagus • Columnar metaplasia of the distal esophagus at least 3-cm above GE junction or any length with intestinal metaplasia • Incidence • 2% of all endoscopies • 15% of all esophagitis • Types • Fundic • Junctional • Intestinal Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Barrett’s Esophagus • Dx; endoscopy/bx • Complications • Ulceration (50%) • Stricture (30%) • Low grade dysplasia (5-10%) • High grade dysplasia/ Ca in situ • Adenocarcinoma (2%) Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital
Barrett’s Esophagus • Asymptomatic uncomplicated Barret’s • Surveillance and yearly biopsies • Symptomatic uncomplicated Barret’s • treat as GERD • Barret’s Ulcers • aggressive medical therapy, recurrence or failure to heal - surgery • Barret’s Strictures • medical management and esophageal dilation • recurrence or persistence - surgery Nir Hus MD., PhD. Ryder Trauma Center Jackson Memorial Hospital