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Mass Spectrometry Analysis of GoldView. Acridine Orange from Aldrich. Acridine orange dimer. Acridine orange dimer. GoldView. Conclusion. The effective ingredient in GoldView is acridine orange (extremely cheap from Aldrich or Sigma at ~100g/$140!)

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slide1

Mass Spectrometry Analysis of GoldView

Acridine Orange from Aldrich

Acridine orange

dimer

Acridine orange

dimer

GoldView

conclusion
Conclusion
  • The effective ingredient in GoldView is acridine orange (extremely cheap from Aldrich or Sigma at ~100g/$140!)
  • Acridine orange is a known gel stain since 1970s (“Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange”.Proc Natl Acad Sci U S A. 1977 Nov;74(11):4835-8.
  • Acridine orange is a highly toxic and known mutagen!
  • Selected list of papers on acridine orange toxicity:
  • Web, RB. Mutat Res. 1984 Jul;137(1):1-6.
  • Wugmeister, M. Yale J Biol Med. 1983 Jan-Feb;56(1):9-13.
  • Martin, SE.Mutat Res. 1981 Jun;82(1):41-6.
  • Ashad, R. Letters in Applied Microbiology 2006,42:94.