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COMPOSITION OF BLOOD. DR. AYESHA JUNAID MBBS,MCPS,FCPS. Professor of Pathology Consultant Haematology Incharge Blood Transfusion Services SIH. OBJECTIVES: COMPOSITION OF BLOOD. Composition of blood. Little bit of functions of blood.   Plasma and its composition. CELLULAR COMPONENTS:

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COMPOSITION OF BLOOD

DR. AYESHA JUNAID

MBBS,MCPS,FCPS.

Professor of Pathology

Consultant Haematology

Incharge Blood Transfusion Services SIH


OBJECTIVES: COMPOSITION OF BLOOD

Composition of blood.

Little bit of functions of blood.

  Plasma and its composition.

CELLULAR COMPONENTS:

RBCs: their structure, function and count.

WBCs: their types, structure, function & count.

Platelets: their structure, function and count.


Composition of blood
COMPOSITION OF BLOOD

  • 5 LITRE

  • 55% PLASMA

  • 45% CELLULAR

    COMPONENTS


COMPOSITION OF BLOOD

Blood is slightly denser and approximately 3-4 times more viscous than water, blood consists of cells which are suspended in a liquid.

Cellular Components

99% red blood cells, with

white blood cells and

platelets making up the remainder.

Water, of blood has amino acids, proteins, carbohydrates, lipids, hormones, vitamins, electrolytes, dissolved gases, and cellular wastes.


COMPOSITION OF BLOOD

By volume.

Plasma is about 92% water, with plasma proteins as the most abundant solutes.

The main plasma protein groups are

albumin

globulin

fibrinogen

The primary blood gases are

oxygen, carbon dioxide, and

nitrogen.


Composition of blood1
COMPOSITION OF BLOOD

  • Centrifuged blood:

    • Plasma 55%

    • Buffy coat

      • WBCs <1%

      • Erythrocytes

      • Hematocrit 45%.


Composition of bl ood
COMPOSITION OF BLOOD

  • Plasma.

    • 90% water

    • 10% solutes

  • Ions, e.g., Na+, Cl-, Ca++

  • Nutrients, e.g., simple sugars, amino acids, lipids

  • Wastes, e.g., urea, ammonia, CO2

  • Miscellaneous: O2, hormones, vitamins, plasma proteins.


Composition of blood2
COMPOSITION OF BLOOD

Plasma Proteins.

  • Albumin

    • Helps control osmotic pressure

    • Helps control diffusion of water

  • Globulin

    • Includes antibodies

    • Transport proteins (lipids, iron, copper, etc.)

  • Fibrinogen

    • Involved in clotting


Composition of blood3
COMPOSITION OF BLOOD

  • Serum: Blood plasma from which the protein fibrinogen, which causes clotting of the blood, has been removed.

  • For all blood chemistry serum of blood is preferred over plasma


COMPOSITION OF BLOOD

WBC, Total.............(4000/μL -11000/μL)

RBC, Total......M(4.5 - 6.5)m/μL, F(3.85.8)m/μL.

Hemoglobin... M(13.0-18.0)g/dL F(11.6-16.5)g/dL

HCT......................... M(40 - 54)% F(38 - 47)%

MCV..................... (80 - 90)fL

MCH....................... (27 - 32)pg

MCHC..................... (33 - 38)g/dL

Platelet Count....................(150,000-400,000)/μL


Composition of blood4
COMPOSITION OF BLOOD

Red cell indices

  • MCV

  • MCH

  • MCHC

  • RDW


Composition of blood5
COMPOSITION OF BLOOD

  • MCV

  • is a measure of the average red cell volume

  • HCT/RBC

  • Normocytic 75-95 fl

  • Macrocytic >95fl

  • Microcytic <75fl



Composition of blood6
COMPOSITION OF BLOOD

  • MCH

  • Is the average mass of Hemoglobin per red blood cell.

  • HB/RBC

  • MCH:27 -31 pg

  • Anemia : low MCH

  • Cannot increase than normal


Composition of blood7
COMPOSITION OF BLOOD

  • MCHC

  • is a measure of the concentration of Hemoglobin in a given volume of packed red blood cells.

  • MCHC:32 to 36 g/dl

  • Decreases in anemia


Composition of blood8
COMPOSITION OF BLOOD

  • RDW

  • is an index of the variation in cell volume within the red cell population

  • RDW = (Standard deviation ÷ mean cell volume) x 100


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