1 / 12

Carcinogenic Metals

Carcinogenic Metals. International Agency for Research on Cancer (IARC) classification. Group 1: Confirmed human carcinogens As, Be, Cd, Cr(VI), Ni Group 2B: Possibly carcinogenic to humans Co. A model summarizing the major mechanisms involved in Cd carcinogenesis.

cady
Download Presentation

Carcinogenic Metals

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Carcinogenic Metals International Agency for Research on Cancer (IARC) classification Group 1: Confirmed human carcinogens As, Be, Cd, Cr(VI), Ni Group 2B: Possibly carcinogenic to humans Co

  2. A model summarizing the major mechanisms involved in Cd carcinogenesis

  3. Categories of Genes Induced by Cd • Immediate early response genes (IEGs) • Stress response genes • Transcription factors • Translation factors • Miscellaneous genes

  4. Some of the genes induced by cadmium Translational Genes Transcription Factors MTF1 USF NFκB Nrf2 Translation initiation factor 3 Translation elongation factor 1δ

  5. FAS-initiated apoptotic cascade

  6. Proposed pathways for ROS in Cd toxicology and carcinogenesis following acute and chronic exposures

  7. Structure of residues 19 – 44 of β-Catenin phosphorylated on Ser 33 and 37 Oncogenic mutations in codon 33: TCT → TAT Ser → Tyr TCT → TTT Ser → Phe

  8. Role of β-catenin in Wnt signaling pathway Proteasome: protein complex that degrades tagged proteins The α-cadherin/β-Catenin complex connects to the actin via α-Catenin and some actin-binding proteins, forming a rigid cytoskeleton. When cells are exposed to Wnt signal, cell surface receptors are activated and block β-Catenin phosphorylation and its subsequent ubiquitination. β-Catenin is thus diverted from the proteasome, and it accumulates and enters the nucleus, where it finds a partner of the TCF/LEF family. Together, they activate new gene expression programs.

  9. Chromium uptake, intracellular chemistry and damage

  10. Chromium-DNA Adducts

  11. Pathways leading to observation of single-strand DNA breaks (SSB) and double-strand DNA breaks (DSB)

More Related