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Plate 53. Nonspecific Resistance to Disease: Inflammation. Nonspecific Resistance. Inflammation is the same against all microorganisms (hence nonspecific ) Inflammation can occur even if a sterile object is used Inflamed = to be flamed (heated, turns red). Inflammation.

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plate 53

Plate 53

Nonspecific Resistance to Disease: Inflammation

nonspecific resistance
Nonspecific Resistance
  • Inflammation is the same against all microorganisms (hence nonspecific)
  • Inflammation can occur even if a sterile object is used
  • Inflamed = to be flamed (heated, turns red)
inflammation
Inflammation
  • Occurs in lower layers of skin (dermis)
  • Contains:
    • Blood vessels
    • White blood cells
    • Connective tissue
    • Nerve cells
purpose of inflammation
Purpose of Inflammation
  • Prevents the growth of microorganisms
    • Heat inhibits the reproduction of bacteria
    • Phagocytes consume bacteria cells
  • Repairs mechanical damage
    • Rebuilds damaged tissues
symptoms of inflammation
Symptoms of Inflammation
  • 4 defining symptoms:
    • Heat
    • Swelling
    • Pain
    • Redness
beginning of inflammation
Beginning of Inflammation
  • Damaged tissues release histamines, which increase blood flow to the injured area
    • Results in redness
  • Capillaries leak phagocytes and clotting proteins into the wound
    • Results in swelling and heat
phagocytosis
Phagocytosis
  • Neutrophils (white blood cells) phagocytize the following materials:
    • Bacteria
    • Dead cells
    • Debris
  • After filling with material, neutrophils die (and become pus)
healing
Healing
  • After all foreign material is removed, blood vessels decrease in size and quantity
  • Fibroblasts create new fibers (fibrosis) in the injured area, sometimes resulting in scar tissue