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From Gene to Protein. Chapter 17 The Connection Between Genes and Proteins. Objectives. Understand the relationship between genes and proteins Understand the overall process by which genetic information is converted to polypeptides Recognize where and why transcription occurs

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Presentation Transcript
From gene to protein

From Gene to Protein

Chapter 17

The Connection Between

Genes and Proteins


Objectives
Objectives

  • Understand the relationship between genes and proteins

  • Understand the overall process by which genetic information is converted to polypeptides

  • Recognize where and why transcription occurs

  • Recognize where and why translation occurs

  • Understand relevant vocabulary


One gene one enzyme
One Gene, One Enzyme

  • Work of George Beadle and Edward Tatum

  • Bread mold nutrition

  • Inability to metabolize a particular AA is the result of an inability to produce necessary enzymes

  • Genes dictate the production of a specific enzyme

Later modified to reflect the

condition that all proteins are not

enzymes nor are all made of a

single peptide:

One Gene-One Polypeptide


Linking genetic information to the synthesis of proteins
Linking Genetic Information to the Synthesis of Proteins

  • If Genes (bits of information on DNA) contain knowledge of how to assemble a polypeptide, then there must be a process by which information on the DNA is conveyed to the protein making machinery of the cell

  • Transcription: the synthesis of RNA under the direction of DNA

  • Translation: Synthesis of a polypeptide under the direction of mRNA


Overview
Overview

  • Transcription

    • players include:

      • DNA

      • messenger RNA

      • RNA Polymerase

    • Occurs in the nucleus

  • Translation

    • players include:

      • mRNA

      • ribosomal RNA

      • transfer RNA

    • Occurs in the cytosol


Review
Review

  • Nucleotides each consist of a sugar, Phosphate and Base

  • Polymers of nucleotides form either DNA or RNA

  • DNA nucleotides have:

    • Deoxyribose as sugar

    • Bases ATGC

    • Double stranded nucleic acid with complimentary bases pairedas A-T & G-C

    • Found only in the nucleus

  • RNA nucleotides have:

    • Ribose as sugar

    • Bases AUGC

    • Single stranded nucleic acid

    • Found in the nucleus and cytoplasm


3 sequential nucleotides code for 1 aa
3 sequential nucleotides code for 1 AA

  • 4 nucleotide bases cannot independently code for 20 different AA

  • Pairs of bases would only account for 16 AA

  • Triplet bases would give us 64 possible AA that could be coded, exceeding the required amount necessary


Info sharing
Info Sharing

  • Only one strand of the double stranded DNA molecule is involved in transcription (Template Strand)

  • Complimentary nucleotide triplets of mRNA are called a Codon (remember that U is substituted for T as a complimentary pair for A)


Codons deciphered
Codons Deciphered

  • Marshall Nirenberg (1961) deciphered the meaning of the codon UUU

  • All 64 possible codon “words” have been determined

  • Redundancy occurs

  • Start and Stop codons occur

  • Reading frame: sequence and groupings of the words