WINDSOR UNIVERSITY SCHOOL OF MEDICINE . Dr.Vishal Surender.MD. Nervous System Synapses. OBJECTIVES. describe the sites of synthesis and storage of small molecule transmitters in nerve terminals list the ionic mechanisms in the vesicular membrane that facilitate transmitter storage
Excitatory and inhibitory synaptic connections mediating the stretch reflex provide an example of typical circuits within the CNS
Central cholinergic neurons project to widespread areas of the cortex and cholinergic activity is responsible for a wide range of behaviors.
Disruption of cholinergic function can produce amnesia, and anticholinergic medications, at toxic levels, are known to produce delirium and delusions.
Neurochemical and neuropathological degenerative findings in the central cholinergic system have been consistently reported in Alzheimer's disease.
Cholinergic excess or hyperactivity has been postulated to play a role in depression and aggressive behaviors.
Therapeutic Drugs Act within the CNS on ReceptorsAnti-anxiety drugs act on GABAA receptor channels
Benzodiazepines and barbiturates: inhibition in the amygdala involved with the development of fear and anxiety.
The binding pocket for benzodiazepines is located in a subunit cleft between gamma and alpha1 subunits
Agonist binding site for GABA is located between alpha1 and beta2 subunits.
Therapeutic Drugs Act within the CNS on ReceptorsSeveral drugs are used to treat mood disorders
MAO inhibitors to reduce the degradation of noradrenaline and serotonin.