An Overview of Glioblastoma (GBM). Marci Klaassen, MSN and Allen Waziri, MD Department of Neurosurgery University of Colorado School of Medicine. Background. Increased metabolic demand. Necrosis. Microvascular proliferation. Glioblastoma : the miserable truth.
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Marci Klaassen, MSN and Allen Waziri, MD
Department of Neurosurgery
University of Colorado School of Medicine
Microvascular proliferationGlioblastoma : the miserable truth
Prognosis -> poor.
Chemotherapy (Temodar, Avastin)
DEATH (mean 15.4 months)
New treatment options are desperately needed
Sensitivity, specificity and “memory”
“Natural” – the response of evolution to cancer
Requirements for an effective immune response (and therefore effective immunotherapy):
Source of antigen
Clearly present in GBM – EGFRvIII, etc.
Is the brain a site of immunoprivilege? Not really.
Functional Immune System
SUPPRESSION OF VACCINES/IMMUNOTHERAPY
A Randomized Placebo-Controlled Trial Exploring the Efficacy of Oral Arginine Supplementation to Improve Cellular Immune Function in Patients with Glioblastoma Multiforme