Nanomedical Biological Device in Development for Torn ACL Replacement. Francine Goulet , Ph.D., pht. INTRODUCTION.
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Francine Goulet, Ph.D., pht
Ligaments, including ACL, extend between adjacent bone structures and serve a primary function of providing appropriate stability to the joints, especially when subjected to loads in tension or upon torsional movement.
Type I collagen can be regenerated after tissue injury.
However, the anterior cruciate ligament (ACL) has little ability to heal itself.
100, 000 total ruptures / yr (USA)
50,000 reconstructive surgeries / yr (USA)
1/3 patellar tendon + patella and tibia fragments
6 weeks; Vascularisation of the implant
30 weeks: histological and functional recoveries
Tissue engineering seems to be a promising alternative to produce ACL/ligament models:
- for fundamentalstudies in vitro;
- to develop tissue-emgineeredhuman ACL substitutes
To understand ACL healing and to establish new options for torn ACL replacement, the potential of tissue-engineered collagen scaffolds has to be assessed in vitro and in vivo.
Appropriate scaffold is needed to provide support and promote cell adhesion, migration and growth, leading to tissue regeneration.
The scaffold must be biocompatible, biodegradable, suitable for cell attachment, and have a three-dimensional, porous structure.
Since collagen is a major structural element in so many tissues and organs, collagen fibers are a logical choice for scaffolds.
Develop a new alternative for torn ACL replacement through the tissue-engineering approach.
Based on our expertise with tissue-engineeredhumanepidermal substitutes, wepostulatedthat ACL regenerationcanbeachieved by providing a biocompatible scaffoldthatcanbecolonized, remodeled and renewed by living cells in situ post-grafting.
Periodicity: 67 nm