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2004-2005 First Year Review (only Principles drugs have been updated; doesn’t include Derm). 12 March 2014 4:14 PM. Abciximab. Antiplatelet Anti-GPIIb/IIIa receptor antibody. Acetaminophen. Analgesic, Antipyretic. Adalimumab. TNF inhibitor Anti-TNF antibody Used in rheumatoid arthritis.

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2004 2005 first year review only principles drugs have been updated doesn t include derm l.jpg

2004-2005First Year Review(only Principles drugs have been updated; doesn’t include Derm)

12 March 20144:14 PM


Abciximab l.jpg
Abciximab

  • Antiplatelet

  • Anti-GPIIb/IIIa receptor antibody


Acetaminophen l.jpg
Acetaminophen

  • Analgesic, Antipyretic


Adalimumab l.jpg
Adalimumab

  • TNF inhibitor

  • Anti-TNF antibodyUsed in rheumatoid arthritis


Adrenocorticotropin acth l.jpg
Adrenocorticotropin(ACTH)

  • Anterior pituitary hormoneAnticonvulsant

  • Stimulates synthesisand release of cortisol


Alemtuzumab l.jpg
Alemtuzumab

  • Antineoplastic

  • Anti-CD52 antibody


Alfentanil l.jpg
Alfentanil

  • OpioidGeneral anaesthetic

  • Intravenous anaesthetic


Allopurinol l.jpg
Allopurinol

  • AntigoutAntineoplastic (supporting agent)

  • Folic acid analogueXanthine oxidase inhibitor


Amantadine l.jpg
Amantadine

  • AntiviralAntiparkinson

  • Treatment of Influenza A Inhibits replicationat the stage of uncoatingInhibits dopamine release


Amikacin l.jpg
Amikacin

  • Aminoglycoside antibioticBactericidal protein synthesis inhibitor

  • 30S ribosomeFreezes initiation


Aminocaproic acid eaca l.jpg
Aminocaproic acid (EACA)

  • Procoagulant

  • Inhibitor of plasminogen activation(decreases fibrinolysis)


Aminoglutethimide l.jpg
Aminoglutethimide

  • AntineoplasticImmunosuppressive

  • Glucocorticoid antagonistAromatase inhibitor(decreases steroid synthesis)


Aminoglycosides l.jpg
Aminoglycosides

  • AntibioticsBactericidal protein synthesis inhibitors

  • 30S ribosomeFreeze initiation


Amitriptyline l.jpg
Amitriptyline

  • Tricyclic antidepressant (TCA)


Amoxicillin l.jpg
Amoxicillin

  • Penicillin antibioticCell wall synthesis inhibitor Antiulcer

  • Amino penicillinInhibits peptidoglycan cross-linking


Amphetamine l.jpg
Amphetamine

  • Indirect sympathomimeticDrug of abuse

  • ADD treatmentStimulant


Ampicillin l.jpg
Ampicillin

  • Penicillin antibioticCell wall synthesis inhibitor

  • Amino penicillinInhibits peptidoglycan cross-linking


Amsacrine l.jpg
Amsacrine

  • Antineoplastic

  • Miscellaneous


Angiostatin l.jpg
Angiostatin

  • Antineoplastic

  • Angiogenesis inhibitor


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Anistreplase

  • Thrombolytic

  • Streptokinase + plasminogen


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Anti-thymocyte globulin

  • Immunosuppressive

  • Anti-T cell antibody


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Aprotinin

  • Procoagulant

  • Fibrinolytic inhibitorSerine protease inhibitor (“serpin”)Streptokinase inhibitor


Argatroban l.jpg
Argatroban

  • Anticoagulant

  • Direct thrombin inhibitor


L asparaginase l.jpg
L-asparaginase

  • Antineoplastic

  • Protein synthesis inhibitor


Aspirin acetylsalicylic acid asa l.jpg
Aspirin(Acetylsalicylic acid, ASA)

  • NSAID (acetylsalicylate)Analgesic, Anti-inflammatoryAntipyretic, Antiplatelet

  • Irreversible cyclooxygenase inhibitor


Atropine l.jpg
Atropine

  • Anticholinergic

  • AntimuscarinicTreatment for bradycardia, diarrhea, cholinesterase poisoning


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Azathioprine

  • ImmunosuppressiveAntineoplastic

  • Antimetabolite(“pseudofeedback inhibition” of HGPRT and PRP)


Azithromycin l.jpg
Azithromycin

  • Macrolide antibioticBacteriostatic protein synthesis inhibitor

  • 50S ribosome Inhibits translocation


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Aztreonam

  • New b lactam antibiotic

  • Monobactam


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Baclofen

  • Skeletal muscle relaxantAnxiolytic

  • GABAB agonist


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Bacitracin

  • AntibioticCell wall synthesis inhibitor

  • Topical, not a b lactam, Inhibits dephosphorylation of bactoprenol


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Basiliximab

  • Immunosuppressive

  • Anti-CD25 (interleukin 2 receptor) Organ transplant (antirejection)


Benzathine penicillin g l.jpg
Benzathine penicillin G

  • Penicillin antibioticCell wall synthesis inhibitor

  • Inhibits peptidoglycan cross-linking Repository preparation


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Benztropine

  • AnticholinergicAntiparkinson

  • Muscarinic receptor antagonist


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Betamethasone

  • AdrenocorticosteroidGlucocorticoid

  • Anti-inflammatory steroidNot by inhalation


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Bethanecol

  • Cholinomimetic

  • Muscarinic agonistInduces defecation and urinationBronchoconstrictor


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Bleomycin

  • Antineoplastic

  • Natural productAntibiotic


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Bivalirudin

  • Anticoagulant

  • Direct thrombin inhibitor


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Bortezomib

  • Antineoplastic

  • Proteosome inhibitor


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Bradykinin

  • Inflammatory mediator

  • Plasma, hypotension, pain


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Bromocriptine

  • Antiparkinson

  • Dopamine (D2) agonistInhibits prolactin release


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Brupropion

  • Second generation antidepressant


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Buprenorphine

  • Opioid

  • Partial agonist


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Buspirone

  • Sedative/hypnoticAnxiolytic


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Busulfan

  • Antineoplastic

  • Alkylating agent


Butorphanol l.jpg
Butorphanol

  • OpioidAnalgesic

  •  receptor partial agonistor antagonist


C3a c5a l.jpg
C3a, C5a

  • Inflammatory mediators

  • Anaphylatoxins Low molecular weight complement cleavage products


Carbamazepine l.jpg
Carbamazepine

  • Anticonvulsant


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Carbenicillin

  • Penicillin antibioticCell wall synthesis inhibitor

  • Anti-pseudomonal penicillinInhibits peptidoglycan cross-linking


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Carbidopa

  • Antiparkinson

  • Peripheral dopa decarboxylase inhibitor


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Carmustine (BCNU)

  • Antineoplastic

  • Alkylating AgentNitrosourea


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Cefaclor

  • Cephalosporin antibioticCell wall synthesis inhibitor

  • 2nd generationOral


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Cefadroxil

  • Cephalosporin antibioticCell wall synthesis inhibitor

  • 1st generationOral


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Cefepime

  • Cephalosporin antibioticCell wall synthesis inhibitor

  • 4th generationCSF penetration


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Cefotaxime

  • Cephalosporin antibioticCell wall synthesis inhibitor

  • 3rd generationCSF penetration


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Cefoxitin

  • Cephalosporin antibioticCell wall synthesis inhibitor

  • 2nd generation


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Ceftazidime

  • Cephalosporin antibioticCell wall synthesis inhibitor

  • 3rd generation


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Ceftriaxone

  • Cephalosporin antibioticCell wall synthesis inhibitor

  • 3rd generationCSF penetration


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Cefuroxime

  • Cephalosporin antibioticCell wall synthesis inhibitor

  • 2nd generationCSF penetration


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Celecoxib

  • NSAIDAnti-inflammatory

  • Cyclooxygenase 2 (COX-2) inhibitor


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Cephalexin

  • Cephalosporin antibioticCell wall synthesis inhibitor

  • 1st generationOral


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Cephalosporins

  • Antibioticsb lactam

  • Cell wall synthesis inhibitorsInhibit cross-linking of peptidoglycan


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Cephalothin

  • Cephalosporin antibioticCell wall synthesis inhibitor

  • 1st generationOral


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Cetirizine

  • Antihistamine

  • H1 antagonistNon-sedating


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Chloral hydrate

  • Sedative/HypnoticGeneral anaesthetic

  • Acts on GABAA receptor complexSimilar to barbiturates


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Chloramphenicol

  • AntibioticBacteriostatic protein synthesis inhibitor

  • 50S ribosomeInhibits peptide bond formation


Chlordiazepoxide l.jpg
Chlordiazepoxide

  • Sedative/hypnoticAnxiolytic

  • Benodiazepine Acts on GABAA receptor complex


Chlorpheniramine l.jpg
Chlorpheniramine

  • Classical antihistamine

  • H1 antagonist


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Chlorpromazine

  • Antipsychotic

  • Phenothiazine


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Ciprofloxacin

  • Fluoroquinolone antibioticDNA replication inhibitor

  • Inhibits bacterial DNA gyrase


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Cisplatin

  • Antineoplastic

  • MiscellaneousCross-linking agent


Clarithromycin l.jpg
Clarithromycin

  • Macrolide antibioticBacteriostatic protein synthesis inhibitor Antiulcer

  • 50S ribosomeInhibits translocation


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Clavulanic acid

  • b-lactamase inhibitor

  • Combined with antibacterials


Clindamycin l.jpg
Clindamycin

  • AntibioticBacteriostatic protein synthesis inhibitor

  • 50S ribosomeAnaerobic infections


Clopidogrel l.jpg
Clopidogrel

  • Antiplatelet

  • ADP receptor antagonist


Cloxacillin l.jpg
Cloxacillin

  • Penicillin antibioticCell wall synthesis inhibitor

  • Penicillinase resistant penicillinInhibits peptidoglycan cross-linking


Clozapine l.jpg
Clozapine

  • Antipsychotic


Cobalamin cyanocobalamin hydroxocobalamin l.jpg
Cobalamin(cyanocobalamin, hydroxocobalamin)

  • Vitamin

  • Treatment forvitamin B12 deficiency


Cocaine l.jpg
Cocaine

  • Indirect sympathomimeticDrug of abuseTopical anaesthetic

  • StimulantLocal anaesthetic


Codeine l.jpg
Codeine

  • OpioidAnalgesic

  • Weak agonist


Cortisol hydrocortisone l.jpg
Cortisol (Hydrocortisone)

  • AdrenocorticosteroidGlucocorticoid

  • Anti-inflammatory steroid


Cyclophosphamide l.jpg
Cyclophosphamide

  • Antineoplastic

  • Alkylating AgentNitrogen mustard


Cycloserine l.jpg
Cycloserine

  • AntibioticCell wall synthesis inhibitor

  • Secondary TB drugInhibits formation of Park nucleotide


Cyclosporine l.jpg
Cyclosporine

  • ImmunosuppressiveAntineoplastic

  • Binds cyclophilinInhibits calcineurin


Cytarabine arac l.jpg
Cytarabine (AraC)

  • Antineoplastic

  • Antimetabolite


Dacarbazine l.jpg
Dacarbazine

  • Antineoplastic

  • Alkylating Agent


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Daclizumab

  • Immunosuppressive

  • Anti-CD25 (interleukin 2 receptor) antibody Organ transplant (anti-rejection)


Dactinomycin l.jpg
Dactinomycin

  • Antineoplastic

  • Natural productAntibiotic


Dalteparin l.jpg
Dalteparin

  • Anticoagulant

  • LMW HeparinATIII activator


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Dantrolene

  • Skeletal muscle relaxant

  • Ryanodine receptor antagonistTreatment for malignant hyperthermia


Dapsone l.jpg
Dapsone

  • Sulfone antibioticNucleic acid andprotein synthesis inhibitor

  • Inhibits dihydropteroate synthetaseLeprosy


Daunorubicin l.jpg
Daunorubicin

  • Antineoplastic

  • Anthracycline antibiotic Natural product


Deprenyl selegiline l.jpg
Deprenyl/selegiline

  • Antiparkinson

  • Monoamine oxidase B inhibitor(MAO-I)Potentiates effects of L-Dopa


Desipramine l.jpg
Desipramine

  • Tricyclic antidepressant (TCA)


Desmopressin acetate l.jpg
Desmopressin acetate

  • Synthetic analogue ofarginine vasopressin

  • Used in treatment of bleeding disorders


Dexamethasone l.jpg
Dexamethasone

  • AdrenocorticosteroidGlucocorticoidAntineoplasticAntiemetic

  • Anti-inflammatory steroidNot by inhalation


Dextromethorphan l.jpg
Dextromethorphan

  • Opioid

  • Antitussive


Diazepam l.jpg
Diazepam

  • Sedative/hypnoticAnxiolyticAnticonvulsant

  • Benzodiazepine Acts on GABAA receptor complex


Diflunisal l.jpg
Diflunisal

  • NSAIDAnalgesic, Anti-inflammatory Antipyretic

  • Cyclooxygenase inhibitor


Diphenhydramine l.jpg
Diphenhydramine

  • Classical antihistamineAntiemetic

  • H1 antagonist


Diphenoxylate docusate l.jpg
Diphenoxylate docusate

  • Antidiarrheal

  • Opiate


Dipyridamole l.jpg
Dipyridamole

  • Antiplatelet

  • Phosphodiesterase inhibitor(increases cAMP)


Doxorubicin l.jpg
Doxorubicin

  • Antineoplastic

  • Anthracycline antibioticNatural product


Doxycycline l.jpg
Doxycycline

  • Tetracycline antibioticBacteriostatic protein synthesis inhibitor

  • 30S ribosomePrevents aminoacyl tRNA attachment


Drotrecogin alfa activated protein c l.jpg
Drotrecogin alfa(Activated Protein C)

  • Anticoagulant

  • Many actionsTreatment for septic shock


Edrecolomab l.jpg
Edrecolomab

  • Antineoplastic

  • Anti-17-1A antibody


Enflurane l.jpg
Enflurane

  • General anaesthetic

  • Inhaled anaesthetic


Enoxaparin l.jpg
Enoxaparin

  • Anticoagulant

  • LMW HeparinATIII activator


Entacapone l.jpg
Entacapone

  • Antiparkinson

  • Peripheral catechol-o-methyltransferase inhibitor


Ephedra ma huang l.jpg
Ephedra(Ma Huang)

  • Dietary supplement

  • Amphetamine-like stimulant


Eptifibatide l.jpg
Eptifibatide

  • Antiplatelet

  • GPIIb/IIIa antagonist


Erythromycin l.jpg
Erythromycin

  • Macrolide antibioticBacteriostatic protein synthesis inhibitor

  • 50S ribosomeInhibits translocation


Erythropoietin epo l.jpg
Erythropoietin (EPO)

  • Cytokine

  • Primary regulator of RBC synthesis


Etanercept l.jpg
Etanercept

  • TNF inhibitor

  • Tumor necrosis factor receptor+ Fc portion of IgGUsed in rheumatoid arthritis


Ethanol l.jpg
Ethanol

  • Drug of abuse

  • Sedative


Ethosuximide l.jpg
Ethosuximide

  • Anticonvulsant


Etomidate l.jpg
Etomidate

  • General anaesthetic

  • Intravenous anaesthetic


Etoposide l.jpg
Etoposide

  • Antineoplastic

  • Natural productPlant alkaloid


Fentanyl l.jpg
Fentanyl

  • OpioidAnalgesic

  •  receptor agonist


Fexofenadine l.jpg
Fexofenadine

  • Antihistamine

  • H1 antagonistNon-sedating


Flumazenil l.jpg
Flumazenil

  • Benzodiazepine antagonist

  • Acts on GABAA receptor complex


5 fluorouracil l.jpg
5-Fluorouracil

  • Antineoplastic

  • AntimetaboliteThymidylate synthase inhibitor


Fluoxetine l.jpg
Fluoxetine

  • Antidepressant

  • Selective serotonin reuptake inhibitor (SSRI)


Flurazepam l.jpg
Flurazepam

  • Sedative/Hypnotic

  • Benzodiazepine Acts on GABAA receptor complex


Fluorinated quinolones ciprofloxacin norfloxacin l.jpg
Fluorinated Quinolonesciprofloxacin, norfloxacin

  • AntibioticsDNA replication inhibitors

  • Inhibit bacterial DNA gyrase


Folic acid l.jpg
Folic acid

  • Vitamin

  • Treatment for folicacid deficiency


Gefitinib l.jpg
Gefitinib

  • Antineoplastic

  • MiscellaneousTyrosine kinase inhibitor


Gemcitabine l.jpg
Gemcitabine

  • Antineoplastic

  • Antimetabolite


Gemtuzumab l.jpg
Gemtuzumab

  • Antineoplastic

  • Anti-CD33 antibody


Gentamicin l.jpg
Gentamicin

  • Aminoglycoside antibioticBactericidal protein synthesis inhibitor

  • 30S ribosome Freezes initiation


Ginko biloba l.jpg
Ginko biloba

  • Dietary supplement

  • Treatment of Alzheimer symptoms


Glutethimide l.jpg
Glutethimide

  • Sedative/Hypnotic


Haloperidol l.jpg
Haloperidol

  • Antipsychotic


Halothane l.jpg
Halothane

  • General anaesthetic

  • Inhaled anaesthetic


Heparin l.jpg
Heparin

  • Anticoagulant

  • ATIII activator


Heroin l.jpg
Heroin

  • Drug of abuse

  • Opioid


Hirudin l.jpg
Hirudin

  • Anticoagulant

  • Direct thrombin inhibitor(DTI)


Histamine l.jpg
Histamine

  • Inflammatory mediator

  • Stored in mast cells and basophils


Hydrocortisone l.jpg
Hydrocortisone

  • AdrenocorticosteroidGlucocorticoid

  • Anti-inflammatory steroid


4 hydroxycoumarin l.jpg
4-Hydroxycoumarin

  • Oral anticoagulant

  • Vitamin K synthesis inhibitor


Hydroxyurea l.jpg
Hydroxyurea

  • Antineoplastic

  • MiscellaneousRibonucleotide reductase inhibitor


Hydroxyzine l.jpg
Hydroxyzine

  • Classical antihistamine

  • H1 antagonist


Ibritumomab l.jpg
Ibritumomab

  • Antineoplastic

  • Anti-CD20 antibody


Ibuprofen l.jpg
Ibuprofen

  • NSAIDAnalgesic, Anti-inflammatory Antipyretic

  • Reversible cyclooxygenase inhibitor


Imatinib l.jpg
Imatinib

  • Antineoplastic

  • MiscellaneousTyrosine kinase inhibitor


Imipenem cilastatin l.jpg
Imipenem/Cilastatin

  • New b lactam antibiotic

  • Cilastatin inhibits akidney dipeptidase that inactivates imipenem


Imipramine l.jpg
Imipramine

  • Indirect sympathomimeticTricyclic antidepressant (TCA)

  • Antimicturant


Indomethacin l.jpg
Indomethacin

  • NSAIDAnalgesic, Anti-inflammatory, Antipyretic

  • Cyclooxygenase inhibitorTocolyticUterine relaxant


Infliximab l.jpg
Infliximab

  • TNF inhibitor

  • Anti-TNF monoclonal antibodyTreatment of IBD


Interferon alpha l.jpg
Interferon alpha

  • Antiviral for hepatitisAntineoplasticCytokine

  • Anti-angiogenesis


Interleukin 2 l.jpg
Interleukin 2

  • Cytokine Antineoplastic


Interleukin 11 l.jpg
Interleukin 11

  • Cytokine Antineoplastic (supporting agent)


Interleukin 12 l.jpg
Interleukin 12

  • Cytokine Antineoplastic (supporting agent)


Irinotecan l.jpg
Irinotecan

  • Antineoplastic

  • Natural product


Isoflurane l.jpg
Isoflurane

  • General anaesthetic

  • Inhaled anaesthetic


Kallidin l.jpg
Kallidin

  • Inflammatory mediator

  • Plasma, hypotension, pain


Kava kava l.jpg
Kava kava

  • Dietary supplement

  • Stress relief andtreatment of insomnia


Ketamine l.jpg
Ketamine

  • General anaestheticDrug of abuse

  • Sedative


Ketoprofen l.jpg
Ketoprofen

  • NSAIDAnalgesic, Anti-inflammatory,Antipyretic

  • Cyclooxygenase inhibitor


Lepirudin l.jpg
Lepirudin

  • Anticoagulant

  • Direct thrombin inhibitor (DTI)


Levodopa l.jpg
Levodopa

  • Antiparkinson

  • Dopamine precursor


Leucovorin l.jpg
Leucovorin

  • Antineoplastic (supporting agent)

  • Folic acid analogue(used in methotrexate rescue)


Leukotriene b 4 ltb 4 l.jpg
Leukotriene B4 (LTB4)

  • Inflammatory mediator

  • Lipoxygenase productof arachidonate metabolismChemotactic


Leukotrienes c 4 d 4 e 4 ltc 4 ltd 4 lte 4 l.jpg
Leukotrienes C4, D4, E4(LTC4,LTD4,LTE4)

  • Inflammatory mediators

  • Cysteinyl leukotrienesPeptidyl leukotrienesSRS-ALipoxygenase products ofarachidonate metabolism


Lidocaine l.jpg
Lidocaine

  • Class I antiarrhythmicLocal anaesthetic

  • Na+ channel blocker(activated and inactivated channels)


Linezolid l.jpg
Linezolid

  • Oxazolidinone antibioticProtein synthesis inhibitor

  • 50S ribosomal subunit


Lithium l.jpg
Lithium

  • Antidepressant

  • Used to treatmanic/depressive disorder


Lomustine ccnu l.jpg
Lomustine (CCNU)

  • Antineoplastic

  • Alkylating AgentNitrosourea


Loperamide l.jpg
Loperamide

  • Antidiarrheal

  • Opiate


Loratidine l.jpg
Loratidine

  • Antihistamine

  • H1 antagonistNon-sedating


Lorazepam l.jpg
Lorazepam

  • AnxiolyticAnticonvulsant

  • BenzodiazepineActs on GABAA receptor complex


Lysergic acid diethylamide lsd l.jpg
Lysergic acid diethylamide(LSD)

  • Drug of abuse

  • Hallucinogen


Macrolides erythromycin azithromycin clarithromycin l.jpg
Macrolideserythromycin, azithromycin, clarithromycin

  • AntibioticsBacteriostatic protein synthesis inhibitors

  • 50S ribosome


Marijuana l.jpg
Marijuana

  • Drug of abuse

  • Cannabinoid


Mechlorethamine l.jpg
Mechlorethamine

  • Antineoplastic

  • Alkylating AgentNitrogen mustard


Meclofenamate l.jpg
Meclofenamate

  • NSAIDAnalgesic, Anti-inflammatory, Antipyretic

  • Cyclooxygenase inhibitor


Melphalan l.jpg
Melphalan

  • Antineoplastic

  • Alkylating AgentNitrogen mustard


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Meperidine

  • Opioid analgesic

  •  receptor agonist


Mepivacaine l.jpg
Mepivacaine

  • Local anaesthetic


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Meprobamate

  • Sedative/hypnoticAnxiolytic


6 mercaptopurine l.jpg
6-Mercaptopurine

  • Antineoplastic

  • Antimetabolite(“pseudofeedback inhibition” of HGPRT and PRP – purine synthesis)


Mesna l.jpg
Mesna

  • Antineoplastic (supporting agent)

  • Prevent hemorrhagic cystitisdue to cyclophosphamide


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Methicillin

  • Penicillin antibioticCell wall synthesis inhibitor

  • Pencillinase resistant penicillin Inhibits peptidoglycan cross-linking


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Methotrexate

  • ImmunosuppressiveAntineoplastic

  • Folic acid antagonistDihydrofolate reductase inhibitor


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Methylprednisolone

  • AdrenocorticosteroidGlucocorticoid

  • Anti-inflammatory steroidNot by inhalation


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Metronidazole

  • AntibioticAntiparasiticAntiulcer

  • AnaerobesReduction leads to intermediatesthat damage DNA


Minocycline l.jpg
Minocycline

  • Tetracycline antibioticBacteriostatic protein synthesis inhibitor

  • 30S ribosomePrevents aminoacyl tRNA attachment


Mitomycin c l.jpg
Mitomycin C

  • Antineoplastic

  • Natural productAntibiotic


Metamphetamine l.jpg
Metamphetamine

  • Drug of abuse

  • Stimulant


Methadone l.jpg
Methadone

  • Opioid

  •  receptor agonist


Montelukast l.jpg
Montelukast

  • Leukotriene inhibitor

  • LTR1 and LTD4 antagonistAsthma treatment


Morphine l.jpg
Morphine

  • OpioidAnalgesic

  •  receptor agonist


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Muromonab-CD3

  • Immunosuppressive

  • Mouse monoclonal anti-CD3 antibody Organ transplant (anti-rejection)


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Mycophenolate

  • Immunosuppressive

  • Inhibits inosine monophosphate dehydrogenase activity


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Nalbuphine

  • Opioid antagonist

  •  receptor antagonist


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Nalmefene

  • Opioid antagonist


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Nalorphine

  • Opioid antagonist


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Naloxone

  • Opioid antagonist


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Naltrexone

  • Opioid antagonist


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Naproxen

  • NSAIDAnalgesic, Anti-inflammatory, Antipyretic

  • Cyclooxygenase inhibitor


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Nafcillin

  • Penicillin antibioticCell wall synthesis inhibitor

  • Penicillinase resistant penicillinInhibits peptidoglycan cross-linking


Neomycin l.jpg
Neomycin

  • Aminoglycoside antibioticBactericidal protein synthesis inhibitor

  • 30S ribosomeFreezes initiationTopical


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Neostigmine

  • Anticholinesterase

  • VasodilatorTreatment for myaesthenia gravisPromotes defecation and urinationBronchoconstrictor


Netilmicin l.jpg
Netilmicin

  • Aminoglycoside antibioticBactericidal protein synthesis inhibitor

  • 30S ribosomeFreezes initiation


Nicotine l.jpg
Nicotine

  • CholinomimeticDrug of abuse

  • Nicotinic receptor agonist(skeletal muscle contraction)StimulantSmoking cessation medication


Nitrous oxide l.jpg
Nitrous oxide

  • General anaesthetic

  • Inhaled anaesthetic


Non steroidal anti inflammatory drugs nsaids l.jpg
Non-steroidalAnti-inflammatory Drugs (NSAIDs)

  • Analgesic, Anti-inflammatory, Antipyretic

  • Cyclooxygenase inhibitors


Norfloxacin l.jpg
Norfloxacin

  • Fluoroquinolone antibioticDNA replication inhibitor

  • Inhibits bacterial DNA gyrase


Nortriptyline l.jpg
Nortriptyline

  • Tricyclic antidepressant (TCA)


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Omalizumab

  • Anti-asthma

  • Anti-IgE antibody


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Oxacillin

  • Penicillin antibioticCell wall synthesis inhibitor

  • Pencillinase resistant penicillinInhibits peptidoglycan cross-linking


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Oxazepam

  • Sedative/hypnoticAnxiolytic

  • BenzodiazepineActs on GABAA receptor complex


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Oxybutinin

  • Anticholinergic

  • Muscarinic receptor antagonistPrevents urination


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Oxycodone

  • Analgesic

  • Opioid agonist


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Oxytetracycline

  • Tetracycline antibioticBacteriostatic protein synthesis inhibitor

  • 30S ribosomePrevents aminoacyl tRNA attachment


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Paclitaxel

  • Antineoplastic

  • Natural productPlant alkaloid (taxane)


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Palivizumab

  • Antiviral

  • Monoclonal antibody againstthe surface ofrespiratory syncytial virus


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Para-aminosalicylic acid

  • AntibioticNucleic acid andprotein synthesis inhibitor

  • Inhibits dihydropteroate synthetaseSecondary TB drug


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Paraldehyde

  • Sedative/Hypnotic


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Penicillins

  • b lactam antibioticsCell wall synthesis inhibitors

  • Inhibit cross-linking of peptidoglycan


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Penicillin G

  • Penicillin antibioticCell wall synthesis inhibitor

  • Acid labileInhibits peptidoglycan cross-linking


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Penicillin V

  • Penicillin antibioticCell wall synthesis inhibitor

  • More acid resistant than Penicillin GInhibits peptidoglycan cross-linking


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Pentazocine

  • Opioid analgesic

  •  receptor partial agonist or antagonist


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Pentobarbital

  • Sedative/Hypnotic

  • Barbiturate


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Pentostatin

  • Antineoplastic

  • MiscellaneousEnzyme inhibitor(blocks purine synthesis)


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Phencyclidine (PCP)

  • Drug of abuse

  • Hallucinogen


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Phenobarbital

  • Sedative/HypnoticAnticonvulsant

  • Barbiturate


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Phenytoin

  • AnticonvulsantClass I antiarrhythmic

  • Na+ channel blocker(inactivated channels)


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Phytonadione

  • Vitamin K

  • Warfarin antagonist


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Piperacillin

  • Penicillin antibioticCell wall synthesis inhibitor

  • Anti-pseudomonal penicillinInhibits peptidoglycan cross-linking


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Piroxicam

  • NSAIDAnalgesic, Anti-inflammatory, Antipyretic

  • Cyclooxygenase inhibitor


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Platelet Activating Factor (PAF)

  • Inflammatory mediator

  • LipidHypotensive


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Polymyxin B

  • AntibioticDisrupts gram negative cell membrane

  • Binds phosphatidylethanolamineBactericidal


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Pramipexole

  • Antiparkinson

  • Dopamine agonist (non-ergot)


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Prednisone

  • AdrenocorticosteroidGlucocorticoid Antineoplastic

  • Anti-inflammatoryNot by inhalation


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Primidone

  • Anticonvulsant


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Probenecid

  • Uricosuric

  • Adjunct in penicillin therapy


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Procaine

  • Local anaesthetic


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Procaine Penicillin G

  • Penicillin antibioticCell wall synthesis inhibitor

  • Repository preparationInhibits peptidoglycan cross-linking


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Procarbazine

  • Antineoplastic

  • MiscellaneousProbably acts as alkylating agent


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Promethazine

  • Classical antihistamineAntipsychoticAntiemetic

  • H1 antagonist


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Propofol

  • General anaesthetic

  • Intravenous anaesthetic


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Prostaglandin D2 (PGD2)

  • Bronchoconstrictor

  • Cyclooxygenase product of arachidonate metabolism


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Prostaglandin E2 (PGE2)Dinoprostone (Dinoprost)

  • Oxytocic prostaglandinInflammatory mediator

  • Cyclooxygenase product of arachidonate metabolismUterine stimulantCervical ripener


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Prostaglandin F2 (PGF2)

  • Inflammatory mediator

  • Cyclooxygenase product of arachidonate metabolism


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Prostaglandin I2 (PGI2)

Prostacyclin

  • Inflammatory mediator

  • Inhibits platelet aggregationCyclooxygenase product of arachidonate metabolism


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Protamine Sulfate

  • Heparin antagonist


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Quinopristin/Dalfopristin

  • Streptogramin antibioticProtein synthesis inhibitor

  • 50S ribosomal subunit


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Resperidone

  • Antipsychotic


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Rifampin

  • AntibioticNucleic acid synthesis inhibitor

  • Inhibits DNA dependent RNA polymeraseMajor drug for TB


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Rituxumab

  • Antineoplastic

  • Anti-CD20 antibody


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Rofecoxib

  • NSAIDAnti-inflammatory

  • Cyclooxygenase 2 (COX-2) inhibitor


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Ropinirole

  • Antiparkinson

  • Dopamine agonist (non-ergot)


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Sargramostim(GM-CSF)

  • Colony stimulating factor

  • WBC (granulocyte and macrophage)stimulant


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Sertraline

  • Antidepressant

  • Selective serotonin reuptake inhibitor (SSRI)


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Sildenafil

  • Vasodilator

  • Promotes erection


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Silver sulfadiazine

  • Sulfonamide antibioticMicrobial nucleic acidand protein synthesis inhibitor

  • Inhibits dihydropteroate synthetaseTopical


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Sirolimus

Rapamycin

  • Immunosuppressive

  • Binds FKBP, inhibits mTOR (mammalian kinase target of rapamycin) & cell cycle progression


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Spectinomycin

  • AntibioticBacteriostatic protein synthesis inhibitor

  • 30S ribosome


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St. John’s Wort

  • Dietary supplement

  • Antidepressant


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Streptokinase

  • Thrombolytic


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Streptomycin

  • Aminoglycoside antibioticBactericidal protein synthesis inhibitor

  • 30S ribosomeFreezes initiation


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Sufentanil

  • OpioidGeneral anaesthetic

  • Intravenous anaesthetic


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Sulfacetamide

  • Sulfonamide antibioticMicrobial nucleic acidand protein synthesis inhibitor

  • Inhibits dihydropteroate synthetaseTopical


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Sulfadoxine

  • Sulfonamide antibioticMicrobial nucleic acidand protein synthesis inhibitor

  • Dihydropteroate synthetase inhibitor


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Sulfamethoxazole

  • Sulfonamide antibioticMicrobial nucleic acidand protein synthesis inhibitor

  • Inhibits dihydropteroate synthetase


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Sulfisoxazole

  • Sulfonamide antibioticNucleic acid andprotein synthesis inhibitor

  • Inhibits dihydropteroate synthetase


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Sulfonamides

  • AntibioticsNucleic acid andprotein synthesis inhibitors

  • Inhibit dihydropteroate synthetase


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Sulindac

  • NSAIDAnalgesic, Anti-inflammatory, Antipyretic

  • Cyclooxygenase inhibitor


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Tacrolimus

  • ImmunosuppressiveAntineoplastic

  • Binds FKBP (FK506 binding protein)Inhibits calcineurin


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Temazepam

  • Sedative/Hypnotic

  • BenzodiazepineActs on GABAA receptor complex


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Tetracaine

  • Local anaesthetic


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Tetracycline

  • AntibioticBacteriostatic protein synthesis inhibitor Antiulcer

  • 30S ribosomePrevents aminoacyl tRNA attachment


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Thalidomide

  • AntineoplasticLeprosy treatment

  • Anti-angiogenicAnti-TNF


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6-Thioguanine

  • Antineoplastic

  • Antimetabolite (“pseudofeedback inhibition” of HGPRT and PRP – purine synthesis)


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Thiopental

  • General anaesthetic

  • Ultra-short-acting barbiturate


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Thioridazine

  • Antipsychotic

  • Phenothiazine


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Thiotepa

  • Antineoplastic

  • Alkylating agent


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Thiothixene

  • Antipsychotic


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Thromboxane A2 (TXA2)

  • Autacoid

  • Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism


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Ticlopidine

  • Antiplatelet

  • ADP receptor antagonist


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Ticarcillin

  • Penicillin antibioticCell wall synthesis inhibitor

  • Anti-pseudomonal penicillinInhibits peptidoglycan cross-linking


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Tissue plasminogen activators

alteplase, reteplase, tenecteplase

  • Thrombolytics


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Tobramycin

  • Aminoglycoside antibioticBactericidal protein synthesis inhibitor

  • 30S ribosomeFreezes initiation


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Tolterodine

  • Anticholinergic

  • Muscarinic receptor antagonistPrevents urination


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Tositumomab

  • Antineoplastic

  • Anti-CD20 antibody


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Tranylcypromine

  • Antidepressant

  • Monoamine oxidase inhibitor (MAO-I)


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Trastuzumab

  • Antineoplastic

  • Anti-HER2 antibody


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Triazolam

  • Sedative/Hypnotic

  • BenzodiazepineActs on GABAA receptor complex


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Trifluoperazine

  • Antipsychotic

  • Phenothiazine


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Trihexyphenidyl

  • Antiparkinson

  • Antimuscarinic


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Trimethoprim

  • AntibioticProtein and nucleic acidsynthesis inhibitor

  • Folic acid antagonistInhibits bacterial dihydrofolate reductase


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Tripelennamine

  • Classical antihistamine

  • H1 antagonist


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Tumor necrosis factor

  • CytokineAntineoplastic


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Urokinase

  • Thrombolytic


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Valproic acid

  • Anticonvulsant


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Vancomycin

  • AntibioticInhibits cell wall synthesis

  • Not a b lactam


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Vigabatrin

  • Anticonvulsant

  • Irreversible GABA aminotransferase inhibitor


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Vinblastine

  • Antineoplastic

  • Vinca alkaloidNatural product


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Vincristine

  • Antineoplastic

  • Vinca alkaloidNatural product


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Warfarin

  • Anticoagulant

  • Vitamin K synthesis inhibitor


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Zafirlukast

  • Leukotriene inhibitor

  • LTR1 and LTD4 antagonistAsthma treatment


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Zileuton

  • Leukotriene inhibitor

  • 5-lipoxygenase inhibitorUsed in asthma


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Zolpidem

  • Sedative/Hypnotic

  • Non-benzodiazepine


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