wp1 progress report vienna 13 march 2011 n.
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WP1 Progress report Vienna, 13 March 2011. Achievements General. 4 Staff members (1 Image Analyst, 1 part-time Radiologist, 2 Research Assistants) in place Obtained approval from Medicines and Healthcare products Regulatory Agency

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achievements general
AchievementsGeneral
  • 4 Staff members (1 Image Analyst, 1 part-time Radiologist, 2 Research Assistants) in place
  • Obtained approval from Medicines and Healthcare products Regulatory Agency
  • Local Ethical Approval obtained provisionally, pending clarifications
achievements structural imaging
AchievementsStructural Imaging
  • Site survey ✔
  • Site selection ✔
  • Radiological and structural protocols (ADNI-GO) for 3T scanners finalised and Manual sent to sites ✔
  • Image Management System (TrialTracker) and electronic data transfer tool (TrialWire) ✔
  • Sites to upload protocol and return protocol form in progress
  • Sites to scan phantom and send details to IXICO in progress
  • Sites to scan 1 healthy volunteer and send details to IXICO not started

Qualification and start scanning

achievements structural imaging1
AchievementsStructural Imaging

Innsbruck considering to join WP1

achievements magnetic resonance spectroscopy
AchievementsMagnetic Resonance Spectroscopy
  • London, Copenhagen, Utrecht have met and agreed protocol
  • Spectra (anterior cingulate and thalamus) from Copenhagen and Utrecht can be read and give reasonable values
  • The data can provide metabolite ratios
  • Currently exploring whether we can do correction for CSF in the MRS voxel which is a superior approach to the ratio method
milestones
Milestones

Deliverables

  • Qualification of sites, test of electronic data transfer tool
  • 2 Estimate of numbers (200 in total: if 10 sites, 20 patients per site)
  • Completion of preparation work for MRI sites
  • Start scanning
possible concerns
Possible concerns

Combination of MRS data:

- Existing power calculation did not take into account the greater variability of multicentre design

- Increase number of subjects with MRS at each site (~30-40 each: existing plan is for 20 subjects scanned twice in London and Copenhagen, so it would be slightly more than double)

- If datasets cannot be combined, we could explore whether findings are reproduced across sites

planned progress
Planned progress
  • Obtain final approval from local ethics
  • Qualify sites
  • Start recruitment and scanning
  • All sites to continue to scan phantom regularly plus 2 healthy volunteers (from the site) yearly, preferably every 6 months and before and after upgrades