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Principles of Immunology Overview of Innate Immunity 1/19/06. “Education is not preparation for life. Education is life itself.” John Dewey. Review(T/F). Jenner was the first to introduce variolation Innate immune responses are specific T cells are either T-helper or T-cytotoxic cells

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principles of immunology overview of innate immunity 1 19 06

Principles of ImmunologyOverview of Innate Immunity1/19/06

“Education is not preparation for life. Education is life itself.”

John Dewey

review t f
Review(T/F)
  • Jenner was the first to introduce variolation
  • Innate immune responses are specific
  • T cells are either T-helper or T-cytotoxic cells
  • Immunological memory results in an amanestic response
  • All antigens are immunogens
innate immunity
Innate Immunity
  • Nonspecific host defenses that exist prior to exposure to an antigen. Involves the following components:
    • Anatomic
    • Physiologic
    • Phagocytic
    • Inflammatory
word list
Word List
  • Antibody
  • Antigen
  • Complement
  • Endocytosis
  • Humoral
  • Macrophage
  • Monocyte
  • Neutrophil
barriers to antigenic insult
Barriers to Antigenic Insult
  • Anatomic
    • Skin
    • Mucous membranes
  • Physiologic
    • Temperature
    • pH
    • Chemical mediators
cellular and inflammatory components of innate immunity
Cellular and Inflammatory Components of Innate Immunity
  • Cellular
    • Phagocytic cells
  • Inflammatory
    • Vasodilation
    • Capillary permeability
anatomic barriers
Anatomic Barriers
  • Skin
    • Epidermis
    • Dermal layer
    • Sebaceous glands
    • Normal flora
anatomic barriers1
Anatomic Barriers
  • Mucous membranes
    • Physical barrier
    • Secretions
    • Cilia
    • Normal flora
physiologic barriers
Physiologic Barriers
  • Temperature
    • Varies by species
    • Febrile response
      • Endogenous pyrogens
  • pH
    • Skin
    • GI tract
physiologic mediators of innate immunity
Physiologic Mediators of Innate Immunity
  • Chemical mediators
    • Enzymes
    • Interferon
    • Complement
      • Three pathways
        • Classical
        • MB Lectin
        • Alternative
physiologic mediators of innate immunity cont d
Physiologic Mediators of Innate Immunity(cont’d)
  • Chemical mediators
    • Collectins
    • Toll-like receptors
    • Acute phase proteins
cellular component of innate immunity
Cellular Component of Innate Immunity
  • Phagocytic cells
    • Monocytes
    • Neutrophils
    • Macrophages
  • Non-Phagocytic cells
    • Natural killer cells
inflammatory response
Inflammatory Response
  • Hallmarks of inflammation
    • Rubor
    • Tumor
    • Calor
    • Dolor
  • Primary cell
    • Activated macrophage
inflammatory response cont d
Inflammatory Response(cont’d)
  • Biological effects
    • Vasodilation
    • Capillary permeability
    • Phagocyte migration
inflammatory response cont d1
Inflammatory Response(cont’d)
  • Chemical mediators of inflammation
    • Histamine
    • Kinin system
    • Fibrin system