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Principles of Immunology Overview of Innate Immunity 1/19/06

Principles of Immunology Overview of Innate Immunity 1/19/06. “Education is not preparation for life. Education is life itself.” John Dewey. Review(T/F). Jenner was the first to introduce variolation Innate immune responses are specific T cells are either T-helper or T-cytotoxic cells

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Principles of Immunology Overview of Innate Immunity 1/19/06

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  1. Principles of ImmunologyOverview of Innate Immunity1/19/06 “Education is not preparation for life. Education is life itself.” John Dewey

  2. Review(T/F) • Jenner was the first to introduce variolation • Innate immune responses are specific • T cells are either T-helper or T-cytotoxic cells • Immunological memory results in an amanestic response • All antigens are immunogens

  3. Innate Immunity • Nonspecific host defenses that exist prior to exposure to an antigen. Involves the following components: • Anatomic • Physiologic • Phagocytic • Inflammatory

  4. Word List • Antibody • Antigen • Complement • Endocytosis • Humoral • Macrophage • Monocyte • Neutrophil

  5. Barriers to Antigenic Insult • Anatomic • Skin • Mucous membranes • Physiologic • Temperature • pH • Chemical mediators

  6. Cellular and Inflammatory Components of Innate Immunity • Cellular • Phagocytic cells • Inflammatory • Vasodilation • Capillary permeability

  7. Anatomic Barriers • Skin • Epidermis • Dermal layer • Sebaceous glands • Normal flora

  8. Anatomic Barriers • Mucous membranes • Physical barrier • Secretions • Cilia • Normal flora

  9. Physiologic Barriers • Temperature • Varies by species • Febrile response • Endogenous pyrogens • pH • Skin • GI tract

  10. Physiologic Mediators of Innate Immunity • Chemical mediators • Enzymes • Interferon • Complement • Three pathways • Classical • MB Lectin • Alternative

  11. Physiologic Mediators of Innate Immunity(cont’d) • Chemical mediators • Collectins • Toll-like receptors • Acute phase proteins

  12. Cellular Component of Innate Immunity • Phagocytic cells • Monocytes • Neutrophils • Macrophages • Non-Phagocytic cells • Natural killer cells

  13. Inflammatory Response • Hallmarks of inflammation • Rubor • Tumor • Calor • Dolor • Primary cell • Activated macrophage

  14. Inflammatory Response(cont’d) • Biological effects • Vasodilation • Capillary permeability • Phagocyte migration

  15. Inflammatory Response(cont’d) • Chemical mediators of inflammation • Histamine • Kinin system • Fibrin system

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