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1. 19.1 19.2::1.2 1.4. Pericentric inversion. NLE1b - 8 -22b (I). 11.1 11.2 11.5 11.6. 11.1 11.2::11.9 11.7. 11.7 11.9 11.10. 11.6 11.5 11.2::11.9 11.10. 11. 1.5 1.8. 1. 11. 1.1 1.2 1.4. HyA11. HyA11(inv). 19.1 19.2 19.3. reciprocal translocation. 19.4 19.5

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Nle1b 8 22b i

1

19.1

19.2::1.2

1.4

Pericentric

inversion

NLE1b - 8 -22b (I)

11.1

11.2

11.5

11.6

11.1

11.2::11.9

11.7

11.7

11.9

11.10

11.6

11.5

11.2::11.9

11.10

11

1.5

1.8

1

11

1.1

1.2

1.4

HyA11

HyA11(inv)

19.1

19.2

19.3

reciprocal

translocation

19.4

19.5

19.6

19.7

19

HyA19

T1(1/19)

resumed in NLE11&17

1.5

1.8

Pericentric

inversion

13.1

13.2

13.3

13.1

13.2::13.5

13.4

13.4

13.5

13.6

1.1

1.2::19.2

19.3

13

13.3

13.2::13.5

13.6

19.4

19.5

19.6

19.7

19

13

HyA13

HyA1

see next slide

NLE22a

T2(19/1)

resumed in the next slide


Nle1b 8 22b ii

11.1

11.2::11.9

11.7

11.6

11.5::19.6

19.5::13.4

13.5::13.2

13.1

NLE1b - 8 -22b (II)

reciprocal

translocation

reciprocal translocation

11.1

11.2::11.9

11.7

13.1

13.2::13.5

13.4

11

11.1

11.2::11.9

11.7

T2(19/1)

intermediate

previous slide

11.6

11.5::19.6

19.5

19.4

19.3

19.2::1.2

1.1

13.3

13.2::13.5

13.6

19

11.6

11.5

11.2::11.9

11.10

1.1

1.2::19.2

19.3

NLE1b

13

19.4

19.5

19.6

19.7

11

11

19

NLE22a

1

NLE1A

HyA11(inv)

intermediate

previous slide

reciprocal

translocation

13.6

13.5::13.2

13.3

19.4

19.2::1.2

1.1

22.1

22.5

22

22.5

22.1

19.7

19.6::11.5

11.2::11.9

11.10

HyA22

NLE22b

NLE8


Nle 3 7b 18

2

6

24

24

27

2.1

2.3

2.4

2.6

2.1

2.3::6.3

6.4

6.5

6.6

NLE 3 - 7b- 18

reciprocal

translocation

6.1

6.2

6.3

6.4

6.1

6.2::2.4

2.6

2.7

2.9::24.3

24.5

inversion

2.7

2.11

6.5

6.6

27.3

27.2

27.1

27.3

27.2::2.10

2.9::24.2

24.1

27.1

27.2::2.10

2.11

24.1

24.2::2.9

2.10

2.11

NLE18

NLE3

HyA2

HyA6

NLE7A

NLE7b

6.1

6.2::2.4

2.5

2.6

reciprocal

translocation

6

Robertsonian Fusion in NLE/SSY/HLA

ancestor

27.3

27.1

2.7

2.8

2.9

2.10

2.11

27

2

27.3

27.1

24.1

24.2

24.5

24.1

24.2::2.9

2.10

2.11

24.1

24.5

27.1

27.3

intermediate

HyA27

T2/6

HyA24

intermediate

NLE7a


Nle 2 4 6 10 12 15 16

23

NLE 2 - 4 - 6 - 10 - 12- 15- 16

4.1

4.3

5.1

5.2

23.1

23.2

fusion

14.1

14.2

14.3

14.4

23.1

23.2

NEC

14.1

14.2

14.3

14.4

4.4

4.7

5.3

5.7

14

HyA23

HyA14

NLE6

NLE2

HyA4

NLE4

HyA5

9.1

9.4

10.1

10.3

7.1

7.2

7.3

7.5

7.1

7.2

7.3

7.5

12.1

12.4

7

NEOCEN

10.4

10.6

NEC

9.5

9.8

12.5

12.6

NLE10

HyA9

NLE12

HyA12

NLE16

HyA10

HyA7

NLE15


Nle 5 9

8

15

NLE 5 - 9

18.1

18.4::18.9

18.7::8.2

8.3

8.4

8.8

8.1

8.2

8.8

reciprocal

translocation

18.1

18.3

18.4

18.9

18.1

18.3

18.4::18.9

18.7

18.6

18.5

NEC

inversion

18

18

HyA18

HyA18(inv)

HyA8

NLE5

intermediate

pericentric inversion

fusion

8.1

8.2::18.7

18.5::15.2

15.1

15.3

15.5

8.1

8.2::18.7

18.6

18.5

15.1

15.2

15.5

15.1

15.2

15.5

8

18

15

intermediate

HyA15(inv)

HyA15

intermediate

NLE9


Nle11 13 17

20.6

20.4

20.3

20.2::1.7

1.8

NLE11 - 13 - 17

19.1

19.2::1.2

1.4

NLE13

19.1

19.2::1.2

1.4

1.5

1.6::16.5

16.1

reciprocal

translocation

1.5

1.6

1.7

1.8

1

20.1

20.2

20.3

19.1

19.2::1.2

1.4

20.4

20.6

20

NLE17

1

reciprocal

translocation

HyA20

16.1

16.5

16.6

16.7

16.9

T1(1/19)

intermediate

see NLE1b(I)

16

1.5

1.6

1.7::20.2

20.1

20.1

20.2::1.7

1.6:16.5

HyA16

20

16.6

16.7

16.9

T1(1/19)/20

intermediate

NLE11


Nle14 19
NLE14 - 19

3.1

3.2:;3.17

3.15

3.14.2::3.5

3.2::3.17

3.19

3.1

3.2

3.5::3.14.2

3.15

3.17

3.19

inversion

3.1

3.5

3.8

Loop and excission

NEC

3

NLE19

3

3.9

3.14.1

3.14.2

3.19

intermediate

3.13.2

3.14.1::3.5

3.8

3.9

3.10::3.12.1

3.10::3.12.1

3.13.1

3.13.2

3.14.1::3.5

3.8

3.5::3.14.1

3.8

inversion

3.9

3.10

3.11

3.12

3.13.1

3

3.9

3.13.2

3.13.1

NLE14

intermediate


Nle20 21 23 24 25 x

17

21

25

NLE20 - 21 - 23 - 24 - 25 - X

Robertsonian

translocation

inversion

25.4

25.1

17.4

17.3

17.2

17.1::17.4

17.7

28.1>2

17.1

17.2

21.1

21.2

25.1

25.4

28.3

28.4

17.3

17.4

17.7

21.1

21.2

HyA25

NLE23

HyA28

HyA21

NLE20

NLE21

HyA21

X.1

X.2::X.3

X.1

X.2

X.3

X.4

X.2::X.3

X.4

inversion

26.1

26.2

29.1

29.3

NLE24

HyA29

NLE25

HyA26

HyAX

NLEX


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