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Chapter 15

Chapter 15. The Brain and Cranial Nerves. The Brain. The average male adult brain weighs about 3.5 lbs. Composed of 3 divisions: Cerebrum = Cerebral cortex and Basal nuclei Cerebellum – posterior and inferior to cerebrum

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Chapter 15

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  1. Chapter 15 The Brain and Cranial Nerves

  2. The Brain • The average male adult brain weighs about 3.5 lbs. • Composed of 3 divisions: • Cerebrum = Cerebral cortex and Basal nuclei • Cerebellum – posterior and inferior to cerebrum • Brainstem: Diencephalon (Thalamus, Hypothalamus and Epithalamus), Midbrain (superior and inferior colliculi), Pons and Medulla oblongata

  3. Brain Meninges

  4. Arachnoid villi Absorbs CSF back into venous sinuses and blood

  5. Brain Ventricles • Cavities within the cerebrum and brain stem where cerebrospinal fluid (CSF) is manufactured and circulated. • Two lateral ventricles over thalamus and roll out into temporal lobes, medial third and fourth ventricles joined by cerebral aqueduct. • Lateral ventricles look like a Rocky Mountain sheep Rams horns and communicate to third ventricle via interventricular foreamen. • CSF is formed by the ependymal cells of choroid plexus in all four ventricles; is an ultrafiltrate of blood- no cells present; high in Na and K. • CSF circulates through ventricular system as well as central canal of spinal cord and subarachnoid space around brain and spinal cord.

  6. Brain Ventricles

  7. CSF formation and circulation into and from blood vascular system. • CSF provides protection and nourishment to the brain and spinal cord. • Has higher levels of Na and K than blood. • CSF reduces weight of brain (1400 gm to 50 gm).

  8. Cerebrum • Cerebrum composes the vast majority of the brain mass (80%). It is divided into 2 halves or hemispheres, a right and a left hemisphere. • Longitudinal fissure- midsagittal groove dividing the two hemispheres into a right and left side. • Consists of an outer layer of gray matter over white matter (like crust on white bread). • Sulci and gyri = valleys and ridges on surface of cerebral hemispheres. • Five lobes: Frontal, parietal, occipital, temporal and insula.

  9. Brain blood flow and barrier • Blood flow to the brain is provided by the internal carotid arteries and the vertebral arteries. • The blood brain barrier (BBB) is thought to be due to specialized endothelial cells that are influenced by the glial astrocytes. • In the choroid plexus there is also a CSF-BBB formed by the ependymal cells. • The BBB is absent in some places of the 3rd and 4th ventricles at patches called circumventricular organs where some substances may pass into the brain tissue.

  10. Cerebral Cortex • The cortex is the outer layer of the cerebrum is composed of gray matter and is where our “consciousness” is located. • It allows us to be who we are, perceive sensations, comprehend and understand, as well as learn and, communicate with the ability to act and react at a conscious level.

  11. Sulcus or Sulci • sulcus/sulci –the valleys or grooves found between the gyri. Some of these also have specific names. • central sulcus – separates the frontal and parietal lobes.. • lateral sulcus – separates the temporal lobe from the parietal/ frontal lobes. • parieto-occipital sulcus – separates the parietal and occipital lobes.

  12. Gyrus or Gyri • gyrus/gyri – the elevated ridges of tissue in the cortex • 1. precentral gyrus- motor cortex area 4 • 2. post central gyrus- sensory cortex areas 1-3 • - homunculus (little man)- portrays motor and sensory areas of body overlaying precentral and postcentral gyri of the cortex

  13. Sulci and Gyri

  14. Humunculus “little man”

  15. Functional areas of the Cortex Three important areas of cortex • Motor areas control voluntary movement. • Sensory areas provide consciousness and awareness of sensations. • Association areas act mainly to integrate diverse information into decisive and meaningful actions. This is done via interneurons or association neurons.

  16. Cortical motor, sensory and association areas

  17. Motor Areas of Cerebral Cortex • 1° (primary) Motor Cortex – located in the precentral gyrus.Also known as Broadmann’s area # 4. -Contains large Pyramidal neurons that allow us to perform precise and skilled movements with our skeletal muscles. -Motor innervation is contralateral i.e. the left side of the brain controls the right side of the body and vice versa. • Broca’s Area – located superior to lateral sulcus and anterior to precentral gyrus.Associated with motor speech and is usually located in the left hemisphere • Premotor cortex anterior to precentral gyrus (Broadmann 6). thought to be site of memory bank for fine motor skils.

  18. Sensory Areas of Cerebral Cortex • 1° (primary) Somatosensory Cortex – located in the postcentral gyrus of the parietal lobe. Areas 1-3 • Visual Sensory Area – Located on the extreme posterior tip of the occipital lobe.Receives input from retina; is largest cortical sensory area. • Auditory Area – medial aspects of the temporal lobes. • Gustatory Area –parietal lobe deep to the temporal lobe at the tip of the tongue of humunculus.

  19. Cerebral anatomy to know • Longitudinal and transverse fissures • Lateral, Central and Parieto-occipital sulci • Precentral (motor #4) and Postcentral (sensory #1-3) gyri • Lobes: Frontal, Parietal, Temporal, Occipital and Insula • Basal nuclei: Caudate nucleus, Putamen, Globus pallidus • Corpus callosum, septum pellucidum, fornix, and internal capsule

  20. Cerebral anatomy to know • White matter is myelinated neuronal tissue in brain and spinal cord and contains neuronal tracts. • Gray matter is unmyelinated and contains mostly neuronal nuclear groups or nuclei and unmyelinated tracts.

  21. Coronal section

  22. Cerebral White Matter • is composed of myelinated processes. Within the white matter are “roads” of ordered groups of neuron processes called tracts. There are three major types of tracts in the cerebral cortex: • Commissural fibers – connect the gray matter between the two hemispheres. e.g. corpus callosum • Association fibers – connect adjacent gyri in same hemisphere. e.g. visual and auditory association areas. • Projection fibers – these connect to regions outside of the cerebrum e.g. internal capsule; corona radiata

  23. Communication fibers

  24. Communication fibers

  25. Basal Nuclei “Corpus striatum” • Masses of cerebral gray matter buried deep in each hemisphere in the white matter and lateral to the thalamus. • Caudate nucleus, globus pallidus and putamen • Communicate with cortex in controlling movement • Complete function is ??, but may regulate start, stop and intensity of voluntary body movements from cortical levels.

  26. Basal Nuclei “Corpus striatum”

  27. The Limbic System • Concerned with sense of smell in association with long term memory and emotional responses (anger, fear, rage, sex and hunger). • Includes cingulate gyrus, amygdala, hippocampus, septum, fornix, thalamus, hypothalamus and olfactory bulbs.

  28. The Limbic System

  29. Diencephalon • Thalamus is sensory relay nucleus from spinal cord and brainstem regions to the cerebral cortex. Located at top of brainstem, each half is joined by intermediate mass. • Hypothalamus nuclear group just inferior to thalamus consisting of ~ 12 nuclei. Third ventricle is roof. -Main visceral control center for many systems: regulates ANS, GI, cardiovascular centers, sleep/wake, emotions, behavior, hunger/thirst, body temp, memory, sex drive and endocrine system. • Epithalamus pineal gland and habenula produce melatonin for sleep/wake.

  30. Diencephalon, Midbrain, Pons and Medulla

  31. Hypothalamus

  32. Epithalamus -Pineal gland -Habenular nuc.

  33. Cerebral and Diencephalon Functions

  34. Brain stem (see Figure 15.7; p. 422) • Extends from posterior border of diencephalon to the beginning of spinal cord at foreamen magnum. • Consists of Midbrain, Pons, and Medulla oblongata -controls automatic behavior of systems necessary for life (e.g. cardiovascular, respiratory, emetic, etc.) -passageway for all tracts to cerebrum and spinal cord -contains nuclei of many cranial nerves to face and neck • Has same pattern of gray/white matter as spinal cord (i.e. white matter surrounds gray matter)

  35. Brain Stem (Lateral view)

  36. Brain Stem(Diencephalon, Midbrain and Hindbrain)

  37. Midbrain • Lies between a plane that extends from behind pineal gland down to posterior end of mamillary bodies and caudally to the rostral part of the pons. • Central cavity is cerebral aqueduct with tectum (roof) dorsally and cerebral peduncles ventrally. • Periaqueductal gray is involved in fight or flight (Sympathetic) • Contains copra quadrigemina (sup & inf colliculi) which are relay nuclei for vision and hearing, respectively. • Other nuclei include substantia nigra and red nucleus • Contains nuclei for occulomotor (CN-III) and trochlear (CN-IV).

  38. Midbrain/Pons (X-section)

  39. Midbrain/Hindbrain (lateral view)

  40. Reticular Formation • Composed of 100’s of small gray nuclei that extend from medulla, pons and midbrain and project up to the diencephalon, cerebellum and cerebrum. • It receives diverse input and sends a continuous stream of information to cerebral cortex keeping it alert to all activity during sleep and consciousness. It is often referred to as the reticular activating system(RAS). • The motor portion sends neurons to the spinal cord via reticulospinal tracts. • Functions include cardiovascular control, pain control, breathing, swallowing, and habituation to environment.

  41. Reticular Formation

  42. Pons • Bulging region on inferior surface of brain stem. • Lies between the midbrain and medulla oblongata. • Forms a bridge between left and right halves of cerebellum. • Fourth ventricle separates pons from cerebellum. • Cranial nerves V (trigeminal), VI (abducens), and VII (facial) arise from pontine nuclei. • Middle cerebellar peduncles carry fibers from Pons to cerebellum.

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