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Isolated prolonged aPTT

Negative personal and family history of bleeding disorder. Isolated prolonged aPTT. Confirm aPTT. Acute bleeding. Exclude heparin contamination. Occult bleeding. Consider anticoagulant influence. No bleeding. Suspect coagulation factor deficiency or LA. Mixing test.

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Isolated prolonged aPTT

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  1. Negative personal and family history of bleeding disorder Isolated prolonged aPTT Confirm aPTT Acute bleeding Exclude heparin contamination Occult bleeding Consider anticoagulant influence No bleeding Suspect coagulation factor deficiency or LA Mixing test 37C at 0 and 2 hrs aPTT correction Weak / no aPTT correction Suspect clotting factor deficiency Suspect acquired hemophilia or LA Not time and temperature dependent Time and temperature dependent Measure FVIII, IX, XI, XII Measure FVIII and inhibitor Tests for LA Single factor deficiency Acquired hemophilia Negative Positive Lupus Anticoagulant Consult comprehensive care hemophilia center

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