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BOC Sciences BOC Sciences BOCSCI Inc. • Best of Chemicals T: 631-504-6093 • F: 631-614-7828 • E: info@bocsci.com 45-16 Ramsey Road Shirley, NY 11967, USA • www.bocsci.com Certificate of Analysis Linaclotide CAS 851199-59-2 Batch No. B15LNCT0907 Molecular Formula C59H79N15O21S6 Batch size 5.6 g MFG. Date Sep. 07, 2015 Retest Date Sep. 06, 2017 TESTING ITEMS SPECIFICATIONS RESULTS Appearance White or almost white powder White powder HPLC: Retention time is same with the refer- ence substance Conforms Identification Conforms Molecular Ion Mass: 1526.7±1 Purity (HPLC Acetate) NLT 98.0% 98.7% Related substances (HPLC) Total impurities: NMT 2.0% Single impurity: NMT 1.0% Total impurities: 0.5% Single impurity: 0.22 Water (Karl Fischer) NMT 6.0% 4.3% Bacterial endotoxins NMT 5 EU/mg Conforms Assay (anhydrous and Acetate-free) 95.0%~105.0% 100.5% Conclusion Correspond to Specifications QA: Sharon Lee Sharon Lee QC: Mary Murphy Mary Murphy Date: Sep. 11, 2015 Sep. 11, 2015 BOCSCI Inc. All rights reserved.