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Effects of electroconvulsive therapy for depression on health related quality of life

Effects of electroconvulsive therapy for depression on health related quality of life. Adam Kavanagh. Acknowledgements. Prof. Declan McLoughlin Dr. Maria Semkovska , Dr. Ross Dunne, Dr. Martha Noone , Dr. Erik Kolshus , Ana Jelovac , Sinead Lambe , Mary Carton

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Effects of electroconvulsive therapy for depression on health related quality of life

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  1. Effects of electroconvulsive therapy for depression on health related quality of life Adam Kavanagh

  2. Acknowledgements • Prof. Declan McLoughlin • Dr. Maria Semkovska, Dr. Ross Dunne, Dr. Martha Noone, Dr. Erik Kolshus, Ana Jelovac, Sinead Lambe, Mary Carton • Shane McCarron, Ger Ryan, Lucy Kiely

  3. Presentation outline • Depression • Electroconvulsive therapy • Aim • Methodology • Results

  4. Depression Weight Sleep Concentration Psychomotor agitation/ retardation Fatigue Worthlessness/ guilt Suicidal thoughts The symptoms cause clinically significant impairment in functioning • 7% - 12% for men • 20% - 25% for women • 4th highest contributor to total burden of disease • 2nd leading cause of disability by 2020 Low mood or Anhedonia

  5. Electroconvulsive therapy Kavanagh & McLoughlin 2009

  6. Aim • The aim of this study was to compare the effects of 1.5 × ST bitemporal and high dose (6 × ST) RUL ECT administered twice weekly on Health related quality of life (HRQOL)

  7. Methodology • EFFECT-DEP TRIAL(ISRCTN23577151) • Design • Location • Inclusion/ Exclusion • Randomization • Primary outcome • Power

  8. SF-36 • A generic outcome measure • Subjectively rated • Only 36 questions • 8-scale profile of functional health and well-being • Psychometrically-based physical and mental health summary measures • Normative data • Sensitive to change • Most frequently used patient rated outcome measure used in clinical trials (Scoggins & Patrick 2009)

  9. Results

  10. Results

  11. Pre-treatment N (RUL = 36, Bi = 32), 6 months N (RUL = 26, bi = 28), Completed both assessments (RUL = 21, Bi = 22)

  12. Pre-treatment N (RUL = 36, Bi = 32), 6 months N (RUL = 26, bi = 28), Completed both assessments (RUL = 21, Bi = 22)

  13. HRQOL 6 months after ECT for severe depression compared to “normal” population

  14. Predicting HRQOL 6 months after ECT for severe depression

  15. Linear model  MCS score = Treatment parameters (Laterality, dose, seizure duration) + Patient characteristics (Gender, age) + Clinical details (Medications, resistance, remission status, cognitive functioning) Remission status at EOT

  16. Summary • Depression significantly impacts HRQOL • ECT is associated with improvements in subjectively assessed HRQOL • High dose RUL ECT is as effective as standard bitemporal ECT • Persistent deficits 6 months after treatment • Remission status at EOT explained persistent deficits

  17. Strengths & limitations • Strengths • Randomized design • Large sample size • New information about HDRUL ECT • Generalizable results • No difference between participants that completed assessments and those that did not • Robust outcomes measure • Robust data analysis approach • Limitations • Loss of data at 6 months

  18. Health related quality of life • HRQOL – depression • HRQOL – depression and ECT • HRQOL – depression and ECT and NICE ‘03 + ‘09

  19. Electroconvulsive therapy • The UK ECT Review Group (2003) - meta-analysis: • Real ECT more effective than simulated ECT: • 9·7 point difference in HDRS • Janicak et al (1985) – Meta-analysis: • MAOI – ECT more effective by 45% • Tricyclic – ECT more effective by 20% • SSRI – ECT significantly more effective than Paroxetine (Folkerts et al. 1997): • 59% Vs reduction 29% reduction in HDRS score.

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