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Neoplasms L8 Mesenchymal tumours + Hamartomas Soheir Mahfouz

Neoplasms L8 Mesenchymal tumours + Hamartomas Soheir Mahfouz. NEOPLASMS-Definition. NEOPLASM A new growth due to the pathologic proliferation of any cell type (epithelial – mesenchymal, embryonic or neuro-ectodermal) which is characterized by being: purposeless -for no reason

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Neoplasms L8 Mesenchymal tumours + Hamartomas Soheir Mahfouz

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  1. Neoplasms L8Mesenchymal tumours +HamartomasSoheir Mahfouz

  2. NEOPLASMS-Definition NEOPLASM A new growth due to the pathologic proliferation of any cell type(epithelial –mesenchymal, embryonic or neuro-ectodermal) which is characterized by being: purposeless-for no reason progressive Irreversible uncontrolled-not affected by growth inhibitory factors unlimited-cannot be stopped

  3. NEOPLASIA

  4. MESENCHYMAL Neoplasms

  5. Benign mesenchymal tumours

  6. NEOPLASMS-Gross Mesenchymal SOLID MASS BENIGN • Shape:well defined round/oval • Surface: smooth capsulated • Size: variable • Cut sect : homogenous • Colour: like origin 1 colour • Consistency: like origin Lumpectomy

  7. Characters of Benign Mesenchymal tumours MICRO • Pink wavy collagen surrounding tumour mass CAPSULE • Tissue exactly like original Terminology = TISSUE + OMA FIBR oma

  8. Benign FIBROUS= Fibroma FAT= Lipoma CARTLAGE=Chondroma BONE= Osteoma NERVE=Neuroma MUSCLE=Myoma BV=Angioma (hamartomas) MYXOID = Myxoma Malignant sarcoma FIBROUS=Fibrosarcoma FAT= Liposarcoma CARTLAGE=Chondrosarcoma BONE= Osteosarcoma NERVE=Neurosarcoma MUSCLE=Myosarcoma BV=Angiosarcoma MYXOID = Myxosarcoma BM & Lymphoid=Leukemia Lymphoma L7 Outline: MESENCHYMAL TUMOURS

  9. 33 Neurofibroma/Schwannoma • Definition: benign tumour of mesenchmayl neural origin • Features: 1-Spindle cellsin bundles and nucleiarearranged parallelto one another 2- Cells are separated bydelicate pink fibers 3- Tumour has a fibrovascularcapsule

  10. MESENCHYMAL T. Leiomyoma/fibromyoma 34 • Def: Benign tumour arising from smooth muscle fibers • Sites: Uterus-esophagus-stomach-intestine-urinary bladder-skin

  11. 34

  12. MESENCHYMAL T. Leiomyoma 34 34

  13. 34 Leiomyoma

  14. Leiomyoma 34

  15. Neurofibroma/Schwannoma 33 Leiomyoma 34

  16. MESENCHYMAL T. Lipoma 35 • Def: Benign tumour arising from fat cells • Sites: Subcutis – mesenteric – retroperitoneal & omental fat – fat of organs as kidney

  17. 35

  18. MESENCHYMAL T. Lipoma G & M 35

  19. MESENCHYMAL T. Chondroma 37 • Definition Benign tumour arising from cartilage cells • Sites flat bones • Secondary changes common

  20. 37

  21. MESENCHYMAL T. Chondroma 37

  22. Tumour-like lesionsHamartoma Definition: Developmental abnormality with a disordered accumulation of mature tissue normal to the site & forming a mass • Nevi • Hemangioma • Lymphangioma & cystic hygroma • Multiple neurofibromatosis • Osteochondroma

  23. Characteristics of a hamartoma • Are controlled by the body and grow at the same rate of the original tissue and stop growth when that tissue stops growth • Not capsulated • Is present at birth but may manifest later They are just abnormally arranged tissues

  24. Capillary Hemangioma 38

  25. Tumour-like lesionsHamartoma Capillary Hemangioma 38 38

  26. 38

  27. 40 Cavernous hemangioma 40

  28. 40

  29. 39 Cavernous Lymphangioma 40

  30. 39

  31. CYSTIC HYGROMA

  32. GUESS THE TUMOUR???

  33. Guess the tumour ? Lipoma chondroma

  34. Guess the diagnosis ? Capillary hemangioma Cavernous hemangioma Cavernous lymphangioma

  35. RESOURCES 1-Pathology department image collection 2-Mahfouz image collection 3- WEBSITES Important web sites from which many images or text were taken. NB. Those not mentioned may be found on web searches: google , Yahoo & ask.com http://www.pathmax.com/ http://www-medlib.med.utah.edu/WebPath/LABS/LABMENU.html#2 http://www.med.uiuc.edu/PathAtlasf/titlePage.html http://www.medscape.com/pathologyhome http://www.gwumc.edu/dept/path/2F.HTM http://ampat.amu.edu.pl/czasopis/contents.htm http://www.urmc.rochester.edu/smd/pathres/long.html http://www.medscape.com/pathology/cme http://www.mic.ki.se/Diseases/C23.html http://dir.yahoo.com/Health/medicine/pathology/ http://www.iaphomepage.org/ http://search.msn.com/results.aspx?q=Pathology+lectures+on+line&FORM=QBRE2 http://dpalm.med.uth.tmc.edu/faculty/bios/hunter/pathlinks.htm http://www.pathmax.com/main.html http://www.pathguy.com

  36. RESOURCES http://www.emedicine.com/oncology/ http://www.thedoctorsdoctor.com/diseases/liposarcoma.htm#histo http://www.humpath.com/article.php3?id_article=3532 http://www.ec.upstate.edu/path/ http://peir.net/ http://medstat.med.utah.edu/WebPath/webpath.html ATLAS http://www.emedicine.com/asp/image_search.asp?query=actinomycosis&offset=12 http://erl.pathology.iupui.edu/C604/INDEX.HTM http://www.path.uiowa.edu/virtualslidebox/ http://www.mic.ki.se/MEDIMAGES.html#G02.403.776.600 http://www.palms.med.usyd.edu.au/pathology_museum/ http://www.med.uiuc.edu/PathAtlasf/titlePage.html http://images.google.com/imgres?imgurl=http://www.images.md/intermedia/imgagent/mediaget/getwatermarked/ACNCR01-09-55-001&imgrefurl=http://www.images.md/users/explore_chapter.asp%3FID%3DACNCR01-09-55%26colID%3DACNCR01-09%26coltitle%3DBreast%2BCancer&h=80&w=120&sz=11&tbnid=EZu7ubDWDdUUIM:&tbnh=55&tbnw=83&hl=en&start=67&prev=/images%3Fq%3DFine%2BNeedle%2BAspiration%2Bof%2BBreast%26start%3D60%26svnum%3D10%26hl%3Den%26lr%3D%26sa%3DN

  37. RESOURCES http://images.google.com/imgres?imgurl=http://www.hopkinsbreastcenter.org/pathology/benign/1j.jpg&imgrefurl=http://www.hopkinsbreastcenter.org/library/educational_information/benign.shtml&h=380&w=492&sz=289&tbnid=NTEcMCp3mRuZbM:&tbnh=98&tbnw=127&hl=en&start=1&prev=/images%3Fq%3DFine%2BNeedle%2BAspiration%2Bof%2BBreast%26svnum%3D10%26hl%3Den%26lr%3D http://images.google.com/imgres?imgurl=http://www.webpathology.com/slides/thumbnails/Testes_SexCord_GranulosaCellTumor2TN.jpg&imgrefurl=http://www.webpathology.com/case.cfm%3Fcase%3D38&h=76&w=101&sz=6&tbnid=yup1zvPUIS1u3M:&tbnh=58&tbnw=78&hl=en&start=21&prev=/images%3Fq%3Dgranulosa%2Bcell%2Btumour%2Bovary%26start%3D20%26svnum%3D10%26hl%3Den%26lr%3D%26sa%3DN http://screening.iarc.fr/index.php http://web.med.unsw.edu.au/pathology/Pathmus/pathmus.htm#InteractiveImages http://www.hopkinsbreastcenter.org/library/educational_information/benign.shtml http://eulep.anat.cam.ac.uk/Search_Pathbase/index.php?actiontype=search&mpath= http://www.diesis.com/fabrizio/atlas/ Dermatopath http://www.derm.ubc.ca/pathology/micrneurann.htm http://tray.dermatology.uiowa.edu/DPT/DPTutor.htm Reproductive http://images.google.com/imgres?imgurl=http://www.path.sunysb.edu/coursemat/reproimages/thumbs/4thumb.jpg&imgrefurl=http://www.path.sunysb.edu/coursemat/reproslides.htm&h=86&w=120&sz=5&tbnid=aVSQELIjiWfBAM:&tbnh=59&tbnw=83&hl=en&start=25&prev=/images%3Fq%3Dgranulosa%2Bcell%2Btumour%2Bovary%26start%3D20%26svnum%3D10%26hl%3Den%26lr%3D%26sa%3DN Respiratory http://iris.nyit.edu/~edoran/Course/Resp1lect01.htm#NORMAL%20ANATOMY%20LUNGS

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