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INTERACTIVE CASE DISCUSSION: CASE 11. University of Santo Tomas Faculty of Medicine and Surgery Department of Radiology Clk. Alexander L. Gonzales II. CASE 11. 24/M: Right sided flank pain. Patient with flank pain. History and physical examination. Renal colic suspected.
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INTERACTIVE CASE DISCUSSION:CASE 11 University of Santo Tomas Faculty of Medicine and Surgery Department of Radiology Clk. Alexander L. Gonzales II
24/M: Right sided flank pain Patient with flank pain History and physical examination Renal colic suspected Diagnostic imaging ??? Patient is pregnant, or cholecystitis or gynecologic process is suspected Patient has history of radiopaque calculi All other patients
24/M: Right sided flank pain Patient with flank pain History and physical examination Renal colic suspected Diagnostic imaging Patient is pregnant, or cholecystitis or gynecologic process is suspected Patient has history of radiopaque calculi All other patients
Hepatic Veins Spleen Celiac axis Liver SMA Left kidney Right kidney Renal artery Renal vein AORTA IVC
Medullary pyramids Kidney Anatomy Minor Calyx Renal artery Major Calyx Renal vein Sinus Ureter Medulla Renal capsule Cortex
Ultrasound Examination Plain-film radiography Intravenous pyelography if CT is not available Noncontrast helical CT Stone detected Stone not detected Stone detected Stone not detected Clinical suspicion of urolithiasis
Right Kidney Long Axis Anterior Superior Inferior Liver Sinus Cortex Diaphragm Posterior
Left Kidney Long Axis Anterior Inferior Superior Rib Shadow Kidney Posterior Spleen
24/M: Right sided flank pain Imaging modality Sensitivity (%) Specificity (%) Ultrasonography 19 97 Advantages Limitations Accessible Poor visualization of Good for diagnosing of ureteral stones Hydronephrosis and renal stones Requires no ionizing radiation
Ultrasound Examination Plain-film radiography Intravenous pyelography if CT is not available Noncontrast helical CT Stone detected Stone not detected Stone detected Stone not detected Clinical suspicion of urolithiasis
24/M: Right sided flank pain NORMAL STUDY PATIENT
24/M: Right sided flank pain Imaging modality Sensitivity (%) Specificity (%) Plain radiography 45 to 59 71 to 77 Advantages Limitations Accessible Stones in middle section & inexpensive of ureter, phleboliths, radiolucent calculi, extraurinary calcifications and nongenitourinary conditions
Ultrasound Examination Plain-film radiography Intravenous pyelography if CT is not available Noncontrast helical CT Stone detected Stone not detected Stone detected Stone not detected Clinical suspicion of urolithiasis
24/M: Right sided flank pain NORMAL STUDY
24/M: Right sided flank pain PRIOR TO IVP 1 MINUTE
24/M: Right sided flank pain 5 MINUTES 15 MINUTES
24/M: Right sided flank pain 40 MINUTES 45 MINUTES
24/M: Right sided flank pain FULL BLADDER POST VOID
24/M: Right sided flank pain Imaging modality Sensitivity (%) Specificity (%) Intravenous 64 to 87 92 to 94 pyelography Advantages Limitations Accessible Variable-quality imaging Provides information Requires bowel preparation on anatomy and & use of contrast media functioning of both Poor visualization of non- kidneys genitourinary conditions Delayed images required in high-grade obstruction
Ultrasound Examination Plain-film radiography Intravenous pyelography if CT is not available Noncontrast helical CT Stone detected Stone not detected Stone detected Stone not detected Clinical suspicion of urolithiasis
24/M: Right sided flank pain AXIAL VIEW CORONAL VIEW
24/M: Right sided flank pain Imaging modality Sensitivity (%) Specificity (%) Noncontrast helical 95 to 100 94 to 96 computed tomography AdvantagesLimitations Most sensitive & specific Less accessible and radiologic test (i.e., facilitates relatively expensive fast, definitive diagnosis) No direct measure of Indirect signs of the degree of renal function. obstruction Provides information on non- genitourinary conditions
24/M: Right sided flank pain • IMPRESSION: • Obstructing Ureterolithiasis ®, with resultant hyrdroureter and hydronephrosis
UROLITHIASIS DISCUSSION
EPIDEMIOLOGY • 2-4% of general population • 2-3 x more common in males • Caucasian > Oriental > African American • Hot climates > temperate • Types of Stones: • Calcium Stones • Uric Acid Stones • Struvite Stones • Cystine Stones • Nephrolithiasis- stones in the kidney • Ureterolithiasis – stones in the ureter
Calcium Stones • 75%-85% of all renal calculi • Consists of: • Calcium oxalate • Calcium phosphate • Calcium urate • Common in males, • 3rd decade of life • Recurrence rate 2 to 3 years • Familial • Associated with: • Idiopathic hypercalciuria - 50% • Hyperuricosuria – 20% • primary hyperparathyroidism - 5% • Idiopathic – 20%
Struvite Stones • Magnesium ammonium phosphate • 10%-15% of all renal calculi • Dchronicurinary tract infections with gram-negative urease-producing bacteria • Chronic bladder catherization • Common in women • Organisms: • Proteus • Pseudomonas Klebsiellaspecies. • Visualized on radiograph calcium carbonate or calcium phosphate • Produces staghorn calculi
Uric Acid Stones • 5%-8% of renal calculi • Radiolucent, • common in males • Familial • Occur primarily in patients in whom a persistently acid urine (pH<5.5) promotes uric acid precipitation • Example: gout patients that are uric acid overproducers • Also in states of chronic diarrhea
CystineStones • Rare and account for approximately 1% of all renal calculi • Develop in patients with cystinuria due to the insolubility of cystine in the urine • Slightly radioopaque • Due to a hereditary metabolic defect resulting in proximal tubular and jejunal transport of the dibasic amino acids:
RISK FACTORS • Male Gender • Age (to 65) • Low urine volume • Situational • Geography • Heredity • Diet • Medications
Pathophysiology EXCRETE INSOLUBLE SUBSTANCE CONSERVE WATER
Relationship of Stone Location to Symptoms Stone LocationCommon Symptom Kidney Vague Flank Pain, Hematuria
Relationship of Stone Location to Symptoms Stone LocationCommon Symptom Proximal Ureter Renal colic, flank pain, upper abdominal pain
Relationship of Stone Location to Symptoms Stone LocationCommon Symptom Middle section of Renal colic, anterior ureter abdominal pain, flank pain
Relationship of Stone Location to Symptoms Stone LocationCommon Symptom Distal ureter Renal colic, dysuria, urinary frequency, anterior abdominal pain, flank pain
Confirmed stone YES Urgent urologic consultation Emergency: UROSEPSIS, Anuria, Renal Failure NO YES Consider hospital admission: Urologic consultation Refractory pain, Refractory nausea, Extremes of age, Debillated condition NO Symptoms amenable to medical management Referral to urologic clinic Ureteral stone < 5 mm Renal stone or ureteral stone > 5 mm Trial of conservative management Weekly KUB radiographs Stone passes Stone fails to pass within 2-4 weeks TREATMENT