Dr Yasir M Khayyat,MBcHB,FRCPC,FACP. Approach to Liver Function Test. Before you order LFT ask. 600 Ø±ÙŠØ§Ù„. Hepatocellular Necrosis Markers. Markers of synthetic function. INR. Markers of Cholestasis. Liver cell. Liver cell. AST ALT. ALT: Specific from the liver ,Cytosolic Enzyme
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Hepatocellular Necrosis Markers
Markers of synthetic function
Markers of Cholestasis
AST/ALT ratio :
AST Alcohol increase release of mitochondrial AST
ALT in alcohol there is pyridoxal 5 deficiency with decrease in ALT > AST activity
In NAFLD,chronic liver disease:
AST ( early low ,then with progressive disease and cirrhosis increase) , advanced cirrhosis decrease hepatic clearance of AST.
GGT ( Gamma Glutamyl Transpeptidase)
Markers of Hepatic Synthesis: