H.Ghaderian1 1-Deparyment of Microbiology , Faculty of Biological Sciences , Islamic Azad Univercity , Falanarjan Branch , 804515/155 , Esfahan , Iran. : Classification. Family : Herpes viridea Sub family : herpes virinea Genus : simplex Specieas:HSV-1 CL 101 ,HSV-2 strain KN 53690
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1-Deparyment of Microbiology , Faculty of Biological Sciences , Islamic Azad Univercity , Falanarjan Branch , 804515/155 , Esfahan , Iran
common name : herpes symplex virus
1) lesion of the skin , eyes , mouth
Infected neonates produce HSV-specific IgM antibodies
within 3 weeks of acquisition of the viral infection,
which increaserapidly during the first 2 to 3 months
and may remain for as long as 1 year after neonatal infection develops.
with adults with primary HSV infection is decreased.
The first time infection of the pregnantwomen
may lead to severe illness in pregnancy and
may be virus transmission to newborn.
The high risk for death requires prompt diagnostic therforesuggestive that of HSV was identified by PCR
Viral DNA was extracted from all specimens
(tracheal aspirate, liver, lungs, and gut)
By using the QIAamp DNA Mini Kit
Primer for the HSV-2: DNA polymerase gene
The DNA was then used for HSV DNAPCR
showed identical sequences in different specimens.
GenBank BLAST tool
highest similarity was
HSV-1 strain CL 101 and HSV-2 strain KN 53690
• Multi nucleatedepithelial cells
must be treated with an intravenous therapy with acyclovir
Antibodies against the surface glycoproteins gB and gDprophylactic and therapeutic agents inHSV infection
Viral thimydin kinas
cellular thimydin kinase
active ))acyclovir three phosphate
is analog to guanin blocked DNApolymerasefunction
cesarean delivery in a woman with active
genital lesions can reduce risk of acquiring HSV to infant
Antiviral Prophylaxis During Pregnancy
the use of oral acyclovir near the end of pregnancy to suppress genital HSV Because of acyclovir’s safety
HSV-2 : glycoprotein D subunit
vaccine adjuvanted :monophosphorylipid A(MPL)
efficacy was limited to women who were HSV-1 and -2 seronegative before receiving vaccination.