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Scopolamine. Julia Bedell Laci Click Meredith Barr. Where does it come from?. Scopolamine is an alkaloid drug found as a secondary metabolite of plants in the Solanaceae family. Solanaceae s are nightshade plants

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scopolamine

Scopolamine

Julia Bedell

Laci Click

Meredith Barr

where does it come from
Where does it come from?
  • Scopolamine is an alkaloid drug found as a secondary metabolite of plants in the Solanaceae family.
    • Solanaceaes are nightshade plants
    • Examples of plants in the family that produce scopolamine are henbane and jimson weed
  • Jimson Weed
chemical make up
Chemical make up
  • Alkaloid drugs
    • In the tropane group
    • Alkaloid drugs are defined as naturally occurring amines that are produced by a plant
    • Many have anesthetic or analgesic effects
  • Chemical formula
    • C17H21NO4
a drug with a sorted history
A drug with a sorted history!
  • Project MKULTRA
    • In the 1950’s the CIA investigated the use of Scopolamine as a “truth serum”
    • Due to hallucinogenic side effects the drug was determined to be an unreliable interrogation drug
so what do we use it for
So what do we use it for?
  • Scopolamine is used as an anti-nausea medication
  • It is given in patch (transdermal) form to treat nausea associated with motion sickness and chemotherapy.
  • Marketed as Scopoderm and Transderm-V
mechanism of action
Mechanism of Action
  • Scopolamine is an antagonist at muscarinic acetylcholine receptors (M1)
  • Blocking acetylcholine from binding to the receptor blocks Acetylcholine mediated nerve impulses from traveling through the body
mechanism of action7
Mechanism of Action
  • In motion sickness a person feels ill because of conflicting sensory information from the visual senses and balance center in the inner ear.
  • To treat motion sickness this antagonist blocks the acetylcholine mediated nerve impulses to the inner ear where balance is controlled.
other medical uses
Other Medical Uses

Scopolamine is sometimes used for other medical purposes such as:

At one point, Scopolamine was mixed with morphine to produce a state known as “twilight sleep”.

“Twilight sleep” was induced to yield an insensibility to pain without loss of consciousness

  • CNS depressant for pain management
  • Pupil Dilator
  • Paralysis of eye muscles
  • Antispasmodic
the negative side of scopolamine use
The negative side of Scopolamine use
  • Acetylcholine is the major neurotransmitter found in autonomic ganglia, and is the chemical that allows neurons to communicate for sensory input and muscle control.
  • Muscarinic receptors are important for control of:
    • Central Nervous System
    • Parasympathetic control of heart, lungs, and gastrointestinal functioning
negative side of scopolamine cont
Negative side of Scopolamine cont’
  • By blocking Ach- M1 functioning, you could inhibit the Central and Peripheral Nervous System functioning.
  • Acetylcholine antagonists also cause heart rate to increase which can lead to myocardial infarction or angina.
remember
Remember!
  • This drug is highly toxic!
  • It must be used in small doses.
  • An overdose of Scopolamine can cause delirium, paralysis, stupor, heart failure, and death.
other side effects
Other Side Effects
  • Dry mouth
  • Blurred vision
  • Constipation
  • Drowsiness
  • Poor Memory
  • Unequal dilation of pupils (also known as anisocoria)

Anisocoria

negative uses of scopolamine
Negative uses of Scopolamine
  • In recent years the use of Scopolamine for criminal purposes has increased dramatically.
  • Scopolamine is often used as a date rape drug because it causes delirium, hallucinations, and has sedative effects on the victim.
for more information
For more information
  • http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682509.html
  • http://www.drugs.com/mtm/scopolamine.html
  • http://en.wikipedia.org/wiki/Scopolamine
  • http://www.transdermscop.com/ (commercial site)
  • http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1641616