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High Intensity Focused Ultrasound (HIFU) guided by MRI. Christakis Damianou Frederick Institute of Technology, MEDSONIC LTD November 9, 2006 HIFU Basics. Diagnostic ultrasound intensities: < 1 W/cm 2 HIFU intensities: 500-10000 W/cm 2 . Friction with tissue causes heating.

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high intensity focused ultrasound hifu guided by mri

High Intensity Focused Ultrasound (HIFU) guided by MRI.

Christakis Damianou

Frederick Institute of Technology, MEDSONIC LTD

November 9, 2006

hifu basics
HIFU Basics.
  • Diagnostic ultrasound intensities: < 1 W/cm2
  • HIFU intensities: 500-10000 W/cm2.
  • Friction with tissue causes heating.
  • Temperature produced is in the range of 60-100 oC.
  • Tumors cells are destroyed due to excessive heating.
  • Spherically focused ultrasound produces localized heating.
slide3

MRI/HIFU System

Damianou C. et al., Journal of Ultrasound in Medicine and Biology Vol. 30 (3), pp. 397-404, 2004

slide5

MR compatible transducer.

MR compatible transducer

Non-MR compatible transducer

mri monitoring of ultrasound
MRI monitoring of Ultrasound

Hynynen K., Damianou C. “Utrasound surgery", Ultrasound Med. Biol., 1992;19 (1): 91-97.

t2 w fse effect of te
T2-W FSE: effect of TE.

TE=32 ms

TE=64 ms

C. Damianou et al. Journal of Ultrasound in Medicine & Biology 2004:30 (3):397-404.

effect of tr on t1 weighted fse
Effect of TR on T1-Weighted FSE.

TR=300 ms

TR=400 ms

TR=500 ms

TR=700 ms

t1w fspgr effect of tr
T1W FSPGR: effect of TR.

2000 W/cm2 for 5 s

TR=100 ms

TR=50 ms

(4x4 lesions)

1 lesion created using cavitation.

TR=150 ms

TR=300 ms

mri monitoring of hifu in liver
MRI Monitoring of HIFU in liver.

T2-FSE

T1-weighted FSE

Proton Density

Photo

slide12

MRI Monitoring of HIFU in liver.

MRI(Proton density)

Photograph

Pathology

cavitation detection
Cavitation detection.

T1W FSE

T2W FSE

FSPGR

cavitation detection14
Cavitation detection.

T1W FSE

T2W FSE

T1W FSPGR

t2w fse comparison of thermal vs cavitation
T2W FSE-Comparison of thermal vs. cavitation.

1000 W/cm2 (30 s)

3500 W/cm2 (30 s)

temperature elevation thermal mode
Temperature elevation-thermal mode.

Each MRI image is acquired in 5 s (FSPGR).

1000 W/cm2 for 5 s

in vivo results t2w fse
In vivo results (T2W FSE).

1000 W/cm2

2000 W/cm2

3500 W/cm2

slide19

Complete coverage Incomplete coverage

C. Damianou, Journal of Ultrasound in Medicine and Biology 2004; 30 (9):1209-1215.

slide22

MR compatible robot.

PCT/CY2006/000001, 19/1/2006

brain ablation under mri guidance
Brain ablation under MRI guidance.

T1 FSE

T2 FSE

Work done by: K. Ioannides

FLAIR

brain ablation
Brain ablation.

FLAIR

T1-FSE

C. Damianou, K. Ioannides, J of Ultrasound in Medicine and Biology, in press.

brain ablation28
Brain ablation.

T1 FSE

TR=300 ms

TR=500 ms

acknowledgments
Acknowledgments
  • K. Ioannides (M.D.), M. Komodormos (Ph.D.), Y. Chapelon (Ph.D.), N. Milonas (M.Sc.)

Work supported by

  • ULTRASOUND I, (Res. Prom. Found.)
  • SONOTHERM (Res. Prom. Found.)
  • ULTRASOUND II (Res. Prom. Found.)
  • TROY (FP6)
  • N2L (FP6)
  • CDTU (Medical Research foundation of France)
  • MARiUS (FP6)
  • SONOMRI (Ministry of industry of Cyprus)