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A NEW CANDIDATE FOR THE L-NUCLEOSIDES RESERVOIR MALINA JASAMAI Department of Pharmacy, FSKB, UKM. firstname.lastname@example.org
Overview • Nucleoside structure - Mechanism of action • Target compounds - Comparison between thio and oxo and rationale for thio synthesis - L-thionucleosides • Synthetic methodology • Antiviral assay
Introduction • Structure of nucleotide and nucleoside
Thio vs Oxo • Rationale of isostere substitution: • increased stability against nucleoside phosphorylase • reduced toxicity in vivo
Million of Thanks! • Malaysian Government for Phd funding • Dr Claire Simons for her supervision and assistance • Prof Jan Balzarini and staff at Rega Institute • My colleagues in Lab 2.22 and everyone in Medicinal Chemistry discipline