a new candidate for the l nucleosides reservoir l.
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A NEW CANDIDATE FOR THE L-NUCLEOSIDES RESERVOIR
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  1. A NEW CANDIDATE FOR THE L-NUCLEOSIDES RESERVOIR MALINA JASAMAI Department of Pharmacy, FSKB, UKM. malina@medic.ukm.my

  2. Aims and Objectives

  3. Overview • Nucleoside structure - Mechanism of action • Target compounds - Comparison between thio and oxo and rationale for thio synthesis - L-thionucleosides • Synthetic methodology • Antiviral assay

  4. Introduction • Structure of nucleotide and nucleoside

  5. Nucleoside analogues in clinical use

  6. Mechanism of Action

  7. Mechanism of Action

  8. Target Compounds

  9. Thio vs Oxo • Rationale of isostere substitution: • increased stability against nucleoside phosphorylase • reduced toxicity in vivo

  10. Eureka!

  11. Biological Evaluation

  12. Million of Thanks! • Malaysian Government for Phd funding • Dr Claire Simons for her supervision and assistance • Prof Jan Balzarini and staff at Rega Institute • My colleagues in Lab 2.22 and everyone in Medicinal Chemistry discipline