1 / 16

A NEW CANDIDATE FOR THE L-NUCLEOSIDES RESERVOIR

A NEW CANDIDATE FOR THE L-NUCLEOSIDES RESERVOIR. MALINA JASAMAI Department of Pharmacy, FSKB, UKM. malina@medic.ukm.my. Aims and Objectives. Overview. Nucleoside structure - Mechanism of action Target compounds - Comparison between thio and oxo

betty_james
Download Presentation

A NEW CANDIDATE FOR THE L-NUCLEOSIDES RESERVOIR

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. A NEW CANDIDATE FOR THE L-NUCLEOSIDES RESERVOIR MALINA JASAMAI Department of Pharmacy, FSKB, UKM. malina@medic.ukm.my

  2. Aims and Objectives

  3. Overview • Nucleoside structure - Mechanism of action • Target compounds - Comparison between thio and oxo and rationale for thio synthesis - L-thionucleosides • Synthetic methodology • Antiviral assay

  4. Introduction • Structure of nucleotide and nucleoside

  5. Nucleoside analogues in clinical use

  6. Mechanism of Action

  7. Mechanism of Action

  8. Target Compounds

  9. Thio vs Oxo • Rationale of isostere substitution: • increased stability against nucleoside phosphorylase • reduced toxicity in vivo

  10. Eureka!

  11. Biological Evaluation

  12. Million of Thanks! • Malaysian Government for Phd funding • Dr Claire Simons for her supervision and assistance • Prof Jan Balzarini and staff at Rega Institute • My colleagues in Lab 2.22 and everyone in Medicinal Chemistry discipline

More Related