930. Evaluation of Outcomes in Patients Starting Antiretroviral Therapy During Hospitalization Leigh E. Efird, PharmD 1 , Manish Patel, PharmD 1 , and Minh Nguyen, MD 2
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Evaluation of Outcomes in Patients Starting Antiretroviral Therapy During Hospitalization
Leigh E. Efird, PharmD1, Manish Patel, PharmD1, and Minh Nguyen, MD2
Grady Health System, Department of Pharmacy and Drug Information, Atlanta, GA1 and Emory University School of Medicine, Atlanta, GA2
Leigh E. Efird, PharmD
Johns Hopkins Hospital
Department of Pharmacy
600 N Wolfe St
Baltimore, MD 21287
Pager: (410) 434-1108
Background: Combined antiretroviral therapy (CART) is recommended in all patients with an AIDS defining illness. In the past few years patients have been started on CART for urgent indications during their hospitalization. However, little is known on the outcome of those patients.
Methods: This is a retrospective chart review of HIV/AIDS hospitalized patients from 8/1/06 to 3/31/07 who initiated CART during their hospital stay. Excluded were those who continued or restarted CART, and those who did not have follow up at an affiliated clinic. Demographic data, rationale for initiating CART, date of initiation, baseline and subsequent HIV viral load and CD4 count, 6 month mortality, pharmacy pick up as well as frequency of medical follow up were collected. Outcome measures included: proportion on CART at 1, 3, 6 months, percentage with undetectable viral load (UVL [<400 copies/ml]), mean CD4 count and mortality at 3 and 6 months. Analysis of the data for continuous and categorical variables were performed using SAS 9.1.
Results: Forty four patients were identified, of which 36 met inclusion criteria. Median age was 43 years, 27 (75 %) male, 35 (97%) Aftrican Americans. Principal reasons for starting inpatient CART were: HIV-associated dementia complex (25%), HIVAN (14%), KS (11%), cryptosporidiosis (11%), PML (6%), PCNSL (3%). One month after initiation, 79% of 28 patients had continued CART uninterrupted, 64% of 25 at 3 months, and 65% of 17 at 6 months. At three months, 86% of 22 patients had UVL. At six months, 64% of 14 patients had UVL. The median CD4 count at baseline was 16, at 3 months 64, and at 6 months 64 cells/mm3 for 36, 24 and 14 evaluable patients respectively. Re-hospitalization rates were 11% at 1 month, 34% at 3 months and 53% at 6 months. Mortality rates were 8% at 1 month, 17% at 3 months and 22% at 6 months.
Conclusions: This study showed that few patients who initiated CART in the hospital remained on it, with the greatest drop off at month after discharge. There is a need to intensify our follow up of those patients at discharge
Duration of Uninterrupted CART
Antiretroviral Therapy Indication
Percent of patients with defined diagnosis, n=36
Disclosure The authors of this presentation have the following disclosures concerning possible financial or personal relationships with commercial entities: Leigh Efird: Nothing to disclose;,Manish Patel: Nothing to disclose; Minh Nguyen: Nothing to disclose
Presented at the 45th Annual IDSA Meeting, October 4-7 2007, San Diego, California