DNA: Structure and Function The DNA Revolution 1940s-1960s Griffith & Avery—DNA transformed pneumococcus bacteria. Encouraged the study of prokaryotic chromosomes. Hershey and Chase—Bacteriophage experiment. DNA from viruses is injected to host bacteria cells. Griffith and Avery
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The two strands are antiparallel.
The backbone of the DNA molecule is composed of alternating phosphate groups and sugars.
The complimentary nitrogenous bases form hydrogen bonds between the strands.
A is complimentary to T and G is complimentary to C.Watson & Crick Model
1 chromosome per cell
Some enzymes and proteins are associated with the DNA.
Not housed in a nucleus.
Several chromosomes per cell.
Histone proteins---”spools”. Same in all eukaryotes
Housed in a nucleus.
Nucleosome—2 loops of DNA wrapped around 8 histone proteins.