RESEARCH AT THE INSTITUTE OF CHEMISTRY - PowerPoint PPT Presentation

RESEARCH AT THE INSTITUTE OF CHEMISTRY

Jim Josephus G. Minglana

Institute of Chemistry

University of the Philippines Diliman

jminglana@chem.upd.edu.ph

04 July 2008

• Analytical Chemistry (9)
• Lilibeth C. Coo
• Florian R. Del Mundo
• Ma. Pythias Espino
• Cynthia Grace C. Gregorio
• Cherrie B. Pascual
• Leni L. Quirit
• Carina Ramos
• Jose S. Solis
• Florenda S. Valera

• Flerida A. Cariño
• Jong Wha Lee
• Inorganic Chemistry (4)
• Ofelia Giron
• Jim Josephus G. Minglana
• Leon M. Payawan Jr.
• Eva Marie A. Ratilla

• Evangeline C. Amor
• Susan R. Arco
• Florecita S. De Guzman
• Mary Ann E. Arias
• Amelia P. Guevara
• Christine C. Hernandez
• Titos A. O. Quibuyen
• Portia Mahal G. Sabido
• Florentino C. Sumera
• Irene M. Villaseñor

• Claro T. Llaguno
• Elma C. Llaguno
• Guillermo M. Nuesca

• Ian Harvey J. Arellano
• Inorganic/Materials Chemistry

• Analytical and Environmental Chemistry Lab
• Analytical Chemistry and Chemical Instrumentation Lab
• Bioactive Metabolites Lab
• Bioorganic and Natural Products Lab 
• Chemical Sensors and Flow Injection Analysis Lab
• Computational and Theoretical Chem
• Lipid Lab 
• Organometallic and Materials Chemistry Research Lab
• Polymer Materials Lab
• Wet Works Synthetic Organic Lab
• Synthetic Organic Chemistry 

Nature of Chemistry Research

Traditional Groupings Multidisciplinary

Analytical Chemistry Bio-Analytical

Computational Chemistry

Biochemistry Drug Design

Nanotechnology

Inorganic ChemistryPolymer & Materials

Organometallic Chemistry

Organic ChemistrySurfaces and catalysis

Instrumentation

Physical Chemistry Bio-Inorganic

Environmental

Natural products

• Sensing
• Energy Generation
• Drug Discovery and Design
• To change every 3-5 (?) years
• To be reviewed yearly

Current Research LabsResearch Thrusts

Anal. & Environ. Chem.

Anal. & Chem. Instru.Sensing

Bioactive Metabolites

Bioorganic & Nat. Prod.

Chem. Sensors & Flow Energy Generation

Injection Anal.

Comput. and Theoretical

LipidDrug Discovery &

Organomet. & Mater. Chem. Design

Polymer Materials

Wet Works Synthetic Organic

Synthetic Organic

• Development of Transition Metal Catalysts for the Electrochemical Reductionof Carbon Dioxide
• Spectroelectrochemical Properties of Transition Metal Clusters
• Development of Photocatalysts for the Degradation of Organic-Based Pollutants
• Ring Opening Metathesis Polymerization using Aqueous OrganorutheniumCatalysts

• Development of transition metal catalysts for the electrochemical reduction of CO2
• Spectroelectrochemical

properties of

transition metal

clusters

Development of photocatalysts for the degradation of organic-based pollutants

• Ring opening metathesis polymerization using aqueous organoruthenium catalysts

• Development of organic reactions in aqueous media
• Development of organic reactions in environmentally benign solvents
• Synthesis of water-tolerant chiral catalysts
• Synthesis of therapeutic compounds and chemical intermediates
• Synthesis of natural products
• Synthesis of organic compounds with extreme redox, interesting photo-physical and –chemical properties

• Development of novel liquid crystalline materials

e.g. Ferroelectric LC, Banana-Shaped LC

• Structure-activity studies through molecular modeling and computational chemistry

• Development of new hybrid materials
• Structure-activity studies through molecular modeling and computational chemistry

• Development of new mesoporous hybrid materials
• Structure-activity studies through molecular modeling and computational chemistry.

ISCRL

:INORGANIC SYNTHESIS &

COMPUTATIONAL RESEARCH LABORATORIES

Isolation, Structure Elucidation and Mechanisms of Action in the Environment

• Humic Substances in the Philippines Environment
• Organic Matter in the Environment

• Potentiometric Sensor Based on Molecularly Imprinted Polymer
• Chemically Modified Electrodes for Selective Detectionof Environmentally SignificantSubstances
• Pesticide Sensors Based on Polysiloxane Modified Graphite Paste Electrodes
• Pervaporation-Flow Injection Methods for the Determination of Sulfur Dioxide/Sulfite in Food and Air samples

• Phytoremediation
• Heavy metals pollution
• Rivers
• Landfills
• Mussels and oyster
• Development of optical chemical sensors for the determination of heavy metals
• Wasted feeds as source of organic and inorganic nitrogen and phosphorus in a marine environment

• Method comparison in the determination of Pb, Cr, and Cd contents in Tuna from Quezon and Davao
• Investigation of levels of BHT (antioxidant) in different food products by High Performance Liquid Chromatography and Gas Chromatography
• UV radiation treatment of POPs pesticides and persistent toxic substances (PTS)
• Analysis of bromate and disinfection by-products in recreational and drinking water

• Methods development for the analysis

of pesticides in water, soil and sediment

• Fate and behavior studies of pesticides and their transformation products in the environment
• Determination of Carbamate Residues in Philippine Agricultural Soil and River Water
• Analysis of Disinfection By-products in Metro Manila Drinking Water
• Biosensors

• Antimicrobial Constituent(s) from Planchonia sp./Excoecaria sp.
• Discovery and Development of Anticancer Drugs and other Agents for Immuno-Liposome-Mediated Delivery to Breast Cancer Cells: PHILFLORA
• Secondary Metabolites from Albizia Species
• Anti-Genotoxic Compounds from L. leucocephala
• Anti-Diabetic Compounds from Philippine Medicinal Plants

• Isolation and structure elucidation of biologically active metabolites from Philippine microalgae and entomopathogenic fungi

• Surface Active Antimicrobial Polyurethane
• Biodegradable Polymers from Coconut Fatty Acids
• Light-Induced Amphiphilic and Antimicrobial Surface Properties of Polyaniline Film
• Visible Light-Induced Hydrogen Gas Production from Conducting Polymer Assisted Photolysis of Water and Water Mixtures

• Mutagenicity and Clastogenicity Potential of Drug Preparations from Philippine Medicinal plants
• Study on B2-microglobulin (B2m) fibril formation
• Study on the encapsulation of anti-cancer drugs using immunoliposomes

for drug delivery

• Enzyme Biotechnology for pesticide degradation
• Hydrolytic enzymes from Metarhizium anisopliae
• Biomarkers research from Gafrarium dispar and Oxyrichthys microlensis.

• Research in organometallic chemistry, catalysis, materials, coordination chemistry, and related topics

Ru3(CO)12 + excess Ph3SiH 

Selected Spectral Data of Product

IR: 2000-2150 cm-1 (CO)

1H NMR: -17.8 ppm (RuH)

Mass: 1100 [M - 2H]+ m/z

Focus on the metal-silicon bond: new discoveries…

• Zeolite/[Ru(bpy)3]2+/TiO2 nanoparticles
• Photovoltaic Thin Film from Polypyrrole Micro-array in Al2O3 Template
• Bacteriorhodopsin L-b-L Growth