IVD Antibody Development Services for Vitamin D Marker

1. IVD Antibody Development Services for Vitamin D Marker With abundant experience in IVD (in vitro diagnostics) antibodies development, Creative Biolabs is able to provide a full range of Vitamin D marker antibodies development services for liver cirrhosis and metabolic disease screening and therapeutic monitoring. Our professional team is optimized to help you with high-quality and cost-effective service to make your project a success. Vitamin D Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and multiple other biological effects. There are several forms of vitamin D exist, the two major forms of which are vitamin D2 and D3. These are known collectively as calciferol. Vitamin D2 and D3can be ingested from the diet and supplements. The major natural source of the vitamin is a synthesis of cholecalciferol in the skin from cholesterol through a chemical reaction that is dependent on sun exposure. Vitamin D has a significant role in calcium homeostasis and metabolism. Calcitriol, a hormone circulating in the blood, has a major role in regulating the concentration of calcium and phosphate and promoting the healthy growth and remodeling of bone. Calcitriol also has other effects, including some effects on cell growth, neuromuscular and immune functions, and reduction of inflammation.

2. Fig.2 Chemical structure of Vitamin D. Vitamin D Marker of Liver Cirrhosis The liver plays an important role in vitamin D metabolism. Vitamins D2 and D3 derived from food and supplements, and vitamin D3 obtained via sunlight exposure, undergo hydroxylation in the liver forming 25-hydroxyvitamin D [25(OH)D], which is then hydroxylated mainly in the kidneys to 1,25 dihydroxy vitamin D [1,25(OH)2D], the biologically active form of vitamin D. The liver also produces bile acids, which are necessary for optimal gastrointestinal absorption of vitamin D obtained from foods or supplements. Vitamin D metabolites undergo enterohepatic circulation, and in the setting of liver dysfunction, impaired excretion of vitamin D metabolites may inhibit production or activation of 25(OH)D. Vitamin D deficiency is often observed in the chronic liver disease. Vitamin D level may be an important survival marker of advanced liver cirrhosis. Different vitamin D levels and the severity of liver failure have a significant relationship with each other in patients with liver cirrhosis, so serum vitamin D level decreases as liver failure severity increases. Vitamin D Marker of Metabolic Bone Disease The primary function of vitamin D is to elevate plasma calcium and phosphorus to normal and supersaturating levels that lead to the mineralization of the skeleton. Vitamin D-resistant failures in mineralization is vitamin D-dependency rickets type I, which preventing encoding the enzyme responsible for converting the circulating form of vitamin D to the active hormone. Also of great importance is vitamin D-dependency rickets type II, which results from mutations in the VDR gene. Some mutations render the VDR inactive and others modify the VDR so that larger doses of the vitamin D hormone are needed to be effective.

3. Vitamin D Marker of Skin Disorders Skin is a target of vitamin D action, as has been clearly established by the presence of the VDR in keratinocytes, sebocytes, and dermal papilla cells and by the suppression of keratinocyte proliferation in vitro by 1,25-(OH)2D3. The discovery that 1,25-(OH)2D3 suppresses keratinocyte proliferation and causes differentiation of promyelocytes to monocytes stimulated interest in the effects of 1,25-(OH)2D3 on keratinocytes. Topical application of 1,25-(OH)2D3 showed promise as a treatment for psoriasis, which is characterized by the hyperproliferation of keratinocytes, indicating the potential use of such compounds for the diagnostic of this disorder. Fig. 3 Vitamin D metabolism. Vitamin D Marker of Melanoma Cancer A role for the vitamin D system in cancer was first suggested by cell culture studies using melanoma cell lines. In these in vitro studies, 1,25-(OH)2D3 was shown to inhibit proliferation and cause the differentiation of the cells at concentrations of ~1 nm. Since then, a large number of epidemiological studies have been published showing inverse relationships between melanoma cancer incidence and ultraviolet irradiation, vitamin D intakes and circulating levels of 1,25-(OH)2D3. Vitamin D Marker Antibodies IVD antibodies are extensively used for disease screening, therapeutic monitoring, and immunology methods such as immunonephelometry and sandwich ELISA. Through our role as a leading antibody IVD company,

4. Creative Biolabs is well-positioned to deliver a focused product to the research market representing the highest value targets for the diagnosis and prognosis of liver cirrhosis and metabolic disease. Creative Biolabs has focused on IVD antibodies discovery for years. We have experts who are able to develop high-affinity IVD antibodies against varies of markers. We are therefore confident in offering the most suitable service and finest results for our customers all over the world. If you are interested in our IVD antibodies discovery services, please contact us for more details. Related Services: IVD Antibodies for Acetylcarnitine Marker IVD Antibodies for Apelin Marker IVD Antibody Development Services for ANGPTL2 Marker IVD Antibodies for Cyclophilin A (CyPA) Marker IVD Antibodies for Glycine Marker IVD Antibodies Development Services for GDF-11 Marker IVD Antibodies Development Services for Gal-3 Marker IVD Antibodies Development Services for Irisin Marker IVD Antibodies Development Services for Lysophosphatidic Acid Marker IVD Antibodies Development Services for Prolactin Marker IVD Antibodies for Sphingomyelin Marker IVD Antibodies Development Services for Urotensin II Marker IVD Antibodies Development Services for VDBP Marker IVD Antibodies Development Services for GCD59 Marker