IVD Antibody Development Services for Creatinine Marker

1. IVD Antibody Development Services for Creatinine Marker With development, Creative Biolabs now provides a full range of creatinine antibody development services for Acute Kidney Injury (AKI) diagnosis and therapeutic monitoring, which not only helps to reflect clinical conditions but also contributes to the design of the immune intervention. Our scientific group specialized in IVD studies is willing to assist you in your research with a timely and cost-effective method. abundant experience in IVD (in vitro diagnostics) antibody Creatinine Creatinine is a byproduct that is derived from muscle metabolism. Creatinine’s formula is C4H7N3O and the molecular weight is 113.1 g/mol. Creatinine is produced from the phosphate of creatine that is a major importance for energy production in muscles. Generally, about 1-2% creatine in the muscles is converted to creatinine every day and creatinine produced at a relatively constant rate by the body. Normally, synthetic creatinine in muscle release into the bloodstream, then almost exclusively filter into the urine by glomerular filtration and is not reabsorbed by the renal tubule includes. Fig. 1 Creatinine-tautomerism-3D-balls. Creatinine Marker of Acute Kidney Injury (AKI) AKI is an abrupt or rapid deficiency of kidney functions. It is a complex clinical syndrome which can influence various biological mechanisms involving

2. immunity, inflammation, apoptosis, and cell cycle. To predict AKI in the early period is difficult, which increases difficulties to develop preventive and therapeutic measures for AKI. Now, more and more evidence reveal that creatinine is a promising indicator to monitor kidney damage or kidney disease. Under normal circumstances, the creatinine production remains essentially unchanged on a daily basis because of the relatively constant muscle mass. Males produce approximately 150-200 micromols of creatinine per kilogram of body weight per 24 hours while females produce approximately 100-150 micromols of creatinine per kilogram of body weight per 24 hours. However, when there is kidney injury, the kidney function will not work efficiently. The kidneys are not able to filter creatinine, as a result of increased creatinine levels in the blood. Hence, the creatinine calculated via measure creatinine levels in blood and urine. And CrCl is associated with glomerular filtration rate (GFR) which is a clinically important indicator of kidney function. Blood creatinine levels may also be solely applied to calculate the GFR. However, the CrCl rate will be exaggerated in the cases of severe renal dysfunction because hypersecretion of creatinine by the proximal tubules will account for a larger portion of the total creatinine secretion. While the usage of ketoacids, cimetidine, and trimethoprim will increase the accuracy of the GFR estimate via reducing creatinine tubular secretion. So, measuring creatinine levels in blood and urine can be used to assess kidney function. clearance (CrCl) may be

3. Fig. 2 Creatinine’s production and clearance. Creatinine Marker Antibodies Creative Biolabs provides IVD antibody development services for creatinine marker with high sensitivity and specificity and can be used for the screening, diagnosis and prediction of AKI patients. Of course, we also provide other antibodies for the screening, therapeutic monitoring and prediction of AKI. If necessary, do not hesitate to contact us. Related Services: IVD Antibody Development Services for Fetuin-A Marker IVD Antibody Development Services for ATF3 Marker IVD Antibody Development Services for KIM-1 Marker IVD Antibody Development Services for NGAL Marker IVD Antibody Development Services for IGFBP-7 Marker IVD Antibody Development Services for Chac1 Marker

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