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SHIP1 deficiency in IBD. Sandra Fernandes 1 , James C. Ryan 2 , William G. Kerr 1 1 SUNY-Upstate Medical University, Syracuse, NY 2 UCSF/SFVA, San Francisco, CA Friday, December 13, 2013. DISCLOSURES. Nothing to disclose. SHIP1 and PI3K / Akt pathway. Fernandes & al., 2013.

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ship1 deficiency in ibd

SHIP1 deficiency in IBD

Sandra Fernandes1, James C. Ryan2, William G. Kerr1

1SUNY-Upstate Medical University, Syracuse, NY

2UCSF/SFVA, San Francisco, CA

Friday, December 13, 2013

disclosures
DISCLOSURES
  • Nothing to disclose
ship1 and pi3k akt pathway
SHIP1 and PI3K/Akt pathway

Fernandes& al., 2013

ship mice
SHIP-/- mice

Germline SHIP1-deficiency cause fatal eosinophilic pneumonia and Crohn’s-like ileitis in mice

For more on SHIP1 and mucosal inflammation in mouse model, please visit poster P-188

Kerr & al., GUT, 2011

western blotting
Western Blotting

SHIP1 : P1C1 + goat anti-mouse HRP, Actin : C-19 + donkey anti-goat HRP, Santa Cruz Biotechnologies

protein degradation or translation inhibition
Protein degradation or translation inhibition?

Modified from Grabbe & al. 2011

Ameres & Zamore, 2013

take home message
Take home message
  • SHIP1-deficiency is found in 10/47 samples (>20% of samples)
  • Both CD and UC
  • SHIP1-deficiency is stable over months
  • No correlation to treatments at time of sampling or to other clinical parameters
  • No reduction in SHIP1 mRNA levels
    • Translational or post-translational
acknowledgments
Acknowledgments
  • William Kerr
  • James Ryan and his team at UCSF/SFVA
  • NeetuSrivastava
  • Raki Sudan
  • Bonnie Toms
  • Robert Brooks
  • Matt Gumbleton
  • Sonia Iyer
  • SudhaNeelam
  • Christie Youngs
  • Katie Miller
  • Scott Stegemann
  • Summer students
  • CCFA (Senior Research Award to WGK)
  • NIH
  • Paige Arnold Butterfly Run
  • Carol M. Baldwin Foundation