Lecture 5 - Serotonin. The serotonergic neuron. Serotonin. serotonin = 5-HT (5-hydroxytryptamine) an ‘indoleamine’ – has an indole ring structure this structure is also found in ‘hallucinogenic’ or ‘psychedelic’ drugs. Indole ring structure. Serotonergic systems. Serotonergic systems.
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Effect of buspirone on self-report ‘contentedness’ after 2 hrs cognitive performance testing (drug had no significant effect on any performance measure) – Chamberlain et al (2007) Journal of Psychopharmacology 21, 210-215
Effects of two SSRIs on Hamilton Depression Rating scores in a randomized, double-blind, placebo-controlled study of 316 patients with major depressive disorder (from Stahl 2000, Biological Psychiatry 48, 894-901)
sertraline v placebo: p < .05 at weeks 12, 20 & 24
citalopram v placebo: p < .01 at weeks 4 to 24
Scores for co-operative behaviour in a 2 person (1 SSRI & 1 placebo) problem-solving task. Behaviour was filmed using hidden camera and scorers were blind to condition.
“Objects appeared to gain in relief; they assumed unusual dimensions; and colours became more glowing. Even self-perception and the sense of time were changed. When the eyes were closed, there surged upon me an uninterrupted stream of fantastic images of extraordinary plasticity and vividness and accompanied by an intense, kaleidoscope-like play of colours.” (Albert Hofmann, discoverer of LSD, 1943)