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MUSCLE AND NERVE. unique to animals conduct electricity (controlled fashion) allow for movement. Actin-Myosin model (board) EXPLAINS: MUSCLE SHORTENING MUSCLE FORCE GENERATION OR “CONTRACTION”. Molecular Basis of Muscle Function. Mechanics of Contraction. Muscle cell is unit

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muscle and nerve

MUSCLE AND NERVE

unique to animals

conduct electricity (controlled fashion)

allow for movement

Human Anatomy, Larry M. Frolich, Ph.D.

molecular basis of muscle function
Actin-Myosin model (board) EXPLAINS:

MUSCLE SHORTENING

MUSCLE FORCE GENERATION OR “CONTRACTION”

Molecular Basis of Muscle Function

Human Anatomy, Larry M. Frolich, Ph.D.

mechanics of contraction
Mechanics of Contraction
  • Muscle cell is unit
  • Role of actin/myosin
  • Action potential or depolarization of membrane makes cell “contract”
  • (motor neuron action potential stimulates muscle membrane depolarization)

Fig. 10.4

Human Anatomy, Larry M. Frolich, Ph.D.

visualizing muscle contraction
Visualizing muscle contraction

How actin-myosin complex (sarcomere)

shorten muscle

Fig. 10.7

Human Anatomy, Larry M. Frolich, Ph.D.

from actin myosin to whole muscle
From Actin-Myosin to Whole Muscle

M & M, Fig. 4.17 for muscle types

Human Anatomy, Larry M. Frolich, Ph.D.

slide6

Skeletal Muscle Tissue(each skeletal muscle is an organ)

  • Cells
    • Long and cylindrical, in bundles
    • Multinucleate
    • Obvious Striations
  • Skeletal Muscles-Voluntary
  • Connective Tissue Components:
    • Endomysium-between fibers
    • Perimysium-surrounds bundles
    • Epimysium-surround whole muscle
    • Attached to bones, fascia, skin
    • Origin & Insertion

Human Anatomy, Larry M. Frolich, Ph.D.

slide7

Smooth Muscle Tissue

  • Cells
    • Single cells, uninucleate
    • No striations
  • Smooth Muscle-Involuntary
    • 2 layers-opposite orientation (peristalsis)
  • Surrounds hollow organs, blood vessels
  • Connective Tissue Component
    • Endomysium: surrounds cells

Human Anatomy, Larry M. Frolich, Ph.D.

slide8

Cardiac Muscle

  • Cells
    • Branching, chains of cells
    • Single or Binucleated
    • Striations
    • Connected by Intercalated discs
  • Cardiac Muscle-Involuntary
  • Myocardium-heart muscle
    • Pumps blood through vessels
  • Connective Tissue Component
    • Endomysium: surrounding cells

Human Anatomy, Larry M. Frolich, Ph.D.

nervous tissue
Neurons are biggest cells in body

Two basic types

motor

sensory

Messages travel by membrane depolarization

Schwann cells are insulation in peripheral nerves (none in CNS)

NERVOUS TISSUE

[Thought game: trip from sensory input (e.g., hot stove) to motor response (e.g., pull back hand]

Human Anatomy, Larry M. Frolich, Ph.D.

neuronal junctions neuron neuron or neuron muscle
NEURONAL JUNCTIONSNeuron-neuron or neuron-muscle
  • NEURO-MUSCULAR JUNCTION

Where neuron transmits signal to muscle to generate action potential

  • SYNAPSE: cell junction where neurons communicate

Human Anatomy, Larry M. Frolich, Ph.D.