Targeted Biologic Agents in Rheumatic Diseases: Antibody and Receptor Therapies

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This figure illustrates the currently approved and in-trial antibody-based and receptor-based biologic agents (highlighted in red) that target primary immune cells (B cells, T cells, macrophages, endothelial cells, osteoclasts, and fibroblasts) alongside circulating mediators such as TNF, IL-15, VEGF, RANKL, BLyS, and CD80/CD86. These agents represent significant advancements in the treatment of rheumatic diseases, as explored by Rothe et al. (2008) in their review of therapeutic innovations utilizing recombinant proteins.

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Jan 18, 2026

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Targeted Biologic Agents in Rheumatic Diseases: Antibody and Receptor Therapies

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Figure 1 Approved or in-trial antibody-based and receptor-based biologic agents (in red) targeting either primary cells (B cells, T cells, macrophages, endothelial cells, osteoclasts and fibroblasts) and/or the circulating mediators (TNF, IL-15, VEGF, RANKL, BLyS, CD80/CD86) involved in rheumatic diseases Rothe A et al. (2008) Therapeutic advances in rheumatology with the use of recombinant proteins Nat Clin Pract Rheumatol doi:10.1038/ncprheum0909

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