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Who is Publishing in My Domain?

Who is Publishing in My Domain?. Ian Gopal Gould UIC – LPPD Dr. Andreas Linninger March 10, 2011.

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Who is Publishing in My Domain?

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  1. Who is Publishing in My Domain? Ian Gopal Gould UIC – LPPD Dr. Andreas Linninger March 10, 2011

  2. Mathematical modeling of CSF pulsatile hydrodynamics based on fluid-solid interaction.Masoumi N, Bastani D, Najarian S, Ganji F, Farmanzad F, Seddighi AS: IEEE Trans Biomed Eng; 2010 Jun;57(6):1255-63 • Modeling paper, applied Linninger et al.'s fluid-solid interaction model of CSF hydrodynamics in ventricular system, setting parameters using clinical data from a group of patients with brain parenchyma tumor. • Modified model by using CSF pulsatile production rate as the major factor of CSF motion. • Calculated ventricle enlargement, CSF pressure distribution and velocity magnitude in the aqueduct and foramina. • Reverse of flow of CSF was predicted. • No existence of large transmural pressure differences was predicted. • The CSF flow pattern and the velocity magnitude were in good agreement with the published models and CINE (phase-contrast magnetic resonance imaging) experiments.

  3. Cerebrospinal fluid dynamics in the human cranial subarachnoid space: an overlooked mediator of cerebral disease. I. Computational model.Gupta S, Soellinger M, Grzybowski DM, Boesiger P, Biddiscombe J, Poulikakos D, Kurtcuoglu V J R Soc Interface; 2010 Aug 6;7(49):1195-204 • Clinical paper, created a 3D, dynamic, subject-specific computational analysis of CSF flow in the subarachnoid space based on MRI data from cliniclaly relevant patients. • Flow velocities were quantified in the anterior and superior SAS. • Abnormal CSF flow is suspected to be a contributor to Alzheimer's through the accumulation of toxic metabolites. • The malfunction of intracranial pressure regulation could lead to disruption of neuroendocrine communication.

  4. Cerebrospinal fluid dynamics in the human cranial subarachnoid space: an overlooked mediator of cerebral disease. II. In vitro arachnoid outflow model.Holman DW, Kurtcuoglu V, Grzybowski DM J R Soc Interface; 2010 Aug 6;7(49):1205-18 • Experimental paper, used cultures of human arachnoid granulation cell. • In vitro model mimics the in vivo characteristics of unidirectional fluid transport. • This agrees with the CSF outflow rates derived from a dynamic, MRI-based computational model of the subarachnoid cranial space. • Intracellular vacuoles of approximately 1 microm in diameter were shown to be the predominant transport mechanism of perfusate.

  5. Cerebrospinal fluid and blood flow in mild cognitive impairment and Alzheimer's disease: a differential diagnosis from idiopathic normal pressure hydrocephalus.El Sankari S, Gondry-Jouet C, Fichten A, Godefroy O, Serot JM, Deramond H, Meyer ME, Balédent O Fluids Barriers CNS; 2011;8(1):12 • Clinical paper, phase-contrast MRI used to quantify CSF flow and cerebral blood flow in patients with Alzheimer's disease and patients with amnesic mild cognitive impairment (a-MCI). • Cerebral blood flow and the pulsatility index were greater in a-MCI patients than in control. • The aqueductal CSF volume was higher in a-MCI patients and even more so in NPH patients. • Aqueductal CSF oscillations are within normal range in Alzheimers patients and are higher than normal in NPH.

  6. Perfusion fluids used in neurosurgery affect cerebrospinal fluid and surrounding brain parenchyma in the rat ventriculocisternal perfusion model.Doi K, Morioka Y, Nishimura M, Kawano T, Harada D, Naito S, Yamauchi A: J Toxicol Sci; 2009 Oct;34(5):511-8 • Experimental paper to validate ARTCEREB, a solution to be used for the irrigation and perfusion of the cerebral ventricles. • Tracked the fate of (14)C-glucose labeled Artcereb perfused into the ventricles in rats. • 90% of the perfused (14)C-glucose labeled Artcereb was distributed to the cerebrospinal tissue and the systemic circulation, tracked via whole body radiography. • Animals perfused with normal saline were associated with serious symptoms including tonic convulsions and death, and exhibited neuronal death in the cerebrum.

  7. The dynamics of brain and cerebrospinal fluid growth in normal versus hydrocephalic mice.Mandell JG, Neuberger T, Drapaca CS, Webb AG, Schiff SJ: J Neurosurg Pediatr; 2010 Jul;6(1):1-10 • Experimental paper, quantified the dynamics of brain and ventricular volume growth in normal and hydrocephalic mice. • Total brain and ventricle volumes were calculated, two different patterns of response were seen in hydrocephalic mice compared with mice with normative growth. • 1. Brain growth was normal despite accumulation of CSF • 2. Abnormal brain enlargement was accompanied by increased CSF volume along with parenchymal edema. • In second pattern, spontaneous ventricular rupture led to normalization of brain CSF volume, implying edema from transmantle pressure gradients. • These 2 patterns of hydrocephalus were significantly discriminable using linear discriminant analysis (p < 0.01). • In contrast, clinically relevant measurements of head circumference or frontal and occipital horn ratios were unable to discriminate between these patterns.

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