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Mechanism of Light Transduction in Rod Membrane

Learn about the intricate process of light transduction in rod cells, from the initial light-opsin interaction to the activation of G-proteins and effector proteins. Understand how this process leads to hyperpolarization of the cell membrane and subsequent signaling cascade.

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Mechanism of Light Transduction in Rod Membrane

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  1. The transduction of light by the rod membrane involves a second messenger mechanism. The first messenger is really the light hitting opsin. Opsin acts as the receptor by activating the G-protein (transducin). Transducin activates the effector protein (phosphodiesterase or PDE) and PDE INactivates the second messenger cGMP. Inactivation removes cGMP from the Na channels and they close, hyperpolarizing the cell membrane, causing the receptor potential, and “activating” the rod. The rod then stops releasing glutamate, allowing the bipolar cell membrane to reach its threshold. (use the vertical slide bar to the right to move between the two slides in this presentation)

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