Antimicrobial Agents. Most other drugs to be covered affect body systems to cure imbalance or malfunction E.g. reduce inflammation, relieve pain, etc. Antimicrobials used to inhibit or destroy living organisms which are “uninvited guests” Drugs must harm invader without harming host
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e.g. Ti = LD50 / ED50
Where LD = lethal dose ED = effective dose
Cross links are both horizontal and vertical between glycan chains stacked atop one another.
There is no molecule similar to peptidoglycan in humans, making drugs that target cell wall synthesis very selective in their toxicity against bacteria.
Differences in structure between prokaryotic and eukaryotic ribosomes make antibiotics that target protein synthesis fairly selectively toxic against bacteria.
Drug entry into host cells and into host mitochondria (w/ prokaryotic ribosomes) apparently not a major problem.