1 / 8

Introduction

Introduction. Hafeez Ul Hassan Education: Master in Photonic (2009-2011) Freidrich Schiller University , Jena, Germany Bachelor of Science in Engineering Sciences (2004-2008) GIK Institute of Engr . & Technology, Pakistan Work Experience : J-fiber GmbH, Jena, Germany

azana
Download Presentation

Introduction

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Introduction Hafeez Ul Hassan Education: Master in Photonic (2009-2011) Freidrich Schiller University , Jena, Germany Bachelor of Science in Engineering Sciences (2004-2008) GIK Institute of Engr. & Technology, Pakistan Work Experience: J-fiber GmbH, Jena, Germany March 2012-August 2013 Manufacturing Technologist (Fiber Preforms) GIK Institute of Engr. & Technology, Pakistan August 2008-August 2009 Electronic Engineer

  2. POF based glucose sensor incorporating grating wavelength fliters

  3. Embedded sensor concept • Continuous glucose monitoring • Self administration of a bio- degradeable sensor with a needle based single use device • Potentially 14 days use time • Insensitive to bio-fouling • Potentially only one single calibration measurement required New sensor incorporating optical fiber

  4. Competitive affinity assay Glucose Sensor Principle: • Based on competitaveaffinityassay • Sensor consist of assayenclosed in permeable memebrane. • AssayChemistry: • Glucose Receptor (Fluorophore labelled) (Donor) • Glucose Analog ( Dye labelled)(Acceptor) • Refrenceflourophore • Making Donor/Acceptor Pair for FRET (Förster Resonance Energy Transfer). • Low glucoseconcentration: more pairing of donor/acceptor. • Flouroscencequenching • High glucoseconcentration:Flouroscenceintensity • Sensor does not consume glucose and reversibly equilibrates with the surrounding tissue. • Sensor calibration is inherently insensitive to bio-fouling and therefore potentially only one single calibration measurement is required. • is based on a competitive affinity assay consisting of a glucose receptor and glucose analog (ligand) contained by a glucose permeable membrane. The glucose sensor does not consume glucose and reversibly equilibrates with the surrounding tissue. Consequently the sensor calibration is inherently insensitive to bio-fouling and therefore potentially only one single calibration measurement is required. The assay is labeled with a fluorophore and a corresponding dye, which together form a FRET pair (Förster Resonance Energy Transfer). The lifetime of the excited state as well as the intensity of the emitted fluorescence correlates with the glucose concentration. Fluorophore labelled glucose receptor Dye labelled glucose analog

  5. Challenges and Tasks for 1st year • Optimized cross section • Response Time • Mechanical stabilization of assay compartment • Optical coupling to assay • Manufacturing • Filtering Milestones for the firstyear • Propose and analyse a number of designs incorportatingFBGs for couplingbetween fiber and assay and /or filteringexcitation and emittedflouroscence . • First design and prototype incorporatingFBGs and optimizedcrosssection.

  6. 1st 3 months activities • LiteratureSurvey • Training events(company/TRIPOD program) • Zemax simulations/geometricalchanges in fiber for efficientcoupling

More Related