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The Science and Ethics of Stem Cell Research. Stem Cell Development Lesson 1. Totipotent : Can become any cell in body or placenta. Pluripotent: Can become any cell in body. Totipotent stem cells. Multipotent: Can become any cell within a specific germ layer or cell lineage.

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Stem cell development lesson 1

The Science and Ethics of

Stem Cell Research

Stem Cell Development

Lesson 1


An overview of early development modeled with play dough

Totipotent: Can become any cell in body or placenta

Pluripotent: Can become any cell in body

Totipotent

stem cells

Multipotent: Can become any cell within a specific germ layer or cell lineage

Multipotent: Can become any cell within a specific germ layer or cell lineage

Fate Decision

Pluripotent

stem cells

(3-5 days old)

Blastocyst

Embryonic stem cells come from inner cell mass of blastocyst.

Gastrulation (day 14) leads to

Primary Germ Cells

Endoderm (inner)gdigestive tract, resp. track

Mesoderm (middle)gbones, blood cells, heart

Ectoderm (outer)gskin, CNS

Gastrulation (day 14) leads to

Primary Germ Cells

Endoderm (inner)gdigestive tract, resp. track

Mesoderm (middle)gbones, blood cells, heart

Ectoderm (outer)gskin, CNS

Fate Decision

Fate Decision

Implantation

Implantation

An Overview of Early Developmentmodeled with Play-Dough

Fertilized egg

Multipotent





Early cell division
Early Cell Division

Source: Florida Institute for Reproductive Science and Technologies


Four cell stage 2 days after fertilization
Four-cell stage2 days after fertilization

Source: Florida Institute for Reproductive Science and Technologies


Eight cell stage 3 days after fertilization
Eight-cell stage3 days after fertilization

Courtesy: RWJMS IVF Program

Source: Florida Institute for Reproductive Science and Technologies


Morula 4 days after fertilization 16 cells
Morula 4 days after fertilization16 cells

Source: Florida Institute for Reproductive Science and Technologies



Blastula 5 days after fertilization
Blastula5 days after fertilization

Source: Florida Institute for Reproductive Science and Technologies

Courtesy: RWJMS IVF Program


Five day embryo
Five Day Embryo

http://www.nationalgeographic.com/ngm/


Blastula blastocyst
Blastula (Blastocyst)

This image has been released into the public domain.



Stem cell development lesson 1

Sea Urchin Development

One Cell to Blastula Stage

  • http://www.luc.edu/depts/biology/dev/urchindv.htm

  • (courtesy of Dr. J. Hardin, Univ. of Wisconsin)

  • http://www.exploratorium.edu/imaging_station/gallery.php?Asset=celldiv&Category=seaurchins&Type=video


Stem cell development lesson 1

Early Mouse

Development

One Cell to Morula Stage



Stem cell development lesson 1

Multipotent

This graphic has been released into the public domain