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5 ft 3 V-blender w/ Spectrometer

5 ft 3 V-blender w/ Spectrometer. Brimrose 5030 wireless process spectrometer collection parameters:. Spectra are collected once every rotation at 23 rpm Tilt sensor triggers spectrometer about 10 ° before bottom 12 spectra are collected and averaged every rotation

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5 ft 3 V-blender w/ Spectrometer

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  1. 5 ft3 V-blender w/ Spectrometer Brimrose 5030 wireless process spectrometer collection parameters: • Spectra are collected once every rotation at 23 rpm • Tilt sensor triggers spectrometer about 10° before bottom • 12 spectra are collected and averaged every rotation • Collection time is 0.45 sec or 62° for 12 spectra off 62° on

  2. Tablet Validation V-Blend MgSt Dispersion 2 ft3 V-blending for 6 minutes 5 mg

  3. Tablet Validation V-Blend MgSt Dispersion 2 ft3 V-blending for 6 minutes 5 mg

  4. Blend Monitoring-NIR Process Spectrometer Romaco blender lid w/ Brimrose 4030 spectrometer mount and sapphire window

  5. Tablet Validation Final Blend 1500L Bin Tumbled for 5 min 15 mg Dotted line represents theoretical MgSt w% of 0.84%

  6. Tablet Validation Final Blend 1500L Bin Tumbled for 5 min 15 mg

  7. Use of NIR During Large Scale Blending 200 ft3 Double Cone Blender outfitted with Brimrose Luminar 4030 AOTF NIR Spectrometer Brimrose 4030 wireless process spectrometer collection parameters: • Spectra are collected once every rotation at 13 rpm • Tilt sensor triggers spectrometer about 10° before bottom • 12 spectra are collected and averaged every rotation • Collection time is 0.51 sec or 40° for 12 spectra off on 40°

  8. API Content in 200 ft3 Double Cone, 13 RPM Target = 49% API RSD in 200 ft3 Double Cone, 13 RPM API Blending w/NIR Monitoring – Conc. & C.U. RSD Initial Blend CU RSD = 1.1% Model Parameters: Wavelengths 1-601 Sample 21-80 1 PC 1st Derivative Gain = 1

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