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This study examines unilateral lower-limb exercise tolerance in individuals with multiple sclerosis (MS) to quantify performance differences between legs. Findings suggest bilateral strength and function variations in MS impact energy demand during exercise. Results emphasize the importance of personalized exercise testing for effective training programs in MS patients.
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Lower-limb performance disparities: Implications for exerciseprescription in multiple sclerosis Rebecca D. Larson, PhD; Kevin K. McCully, PhD; Daniel J. Larson, PhD; William M. Pryor, MS; Lesley J. White, PhD
Aim • Examine unilateral lower-limb exercise tolerance during fixed-load cycling to quantify performance disparities of the legs in individuals with multiple sclerosis (MS). • Relevance • Evidence suggests that individuals with MS exhibit bilateral differences in strength and function. • Such differences may explain higher energy demand during exercise.
Method • 8 individuals with relapsing-remitting MS and 7 controls performed submaximal single-leg cycling.
Results • Individuals with MS: • Performed significantly more work with stronger leg than weaker leg. • Control group: • Displayed no statistical differences between limbs.
Conclusion • Results highlight need for individualized exercise testing when prescribing training programs for those with MS.