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Esclerosis Lateral Amiotrófica

Esclerosis Lateral Amiotrófica. 05.dic.2012. Definición. ELA Antecedentes. Rowland L, et al . Diagnosis of amyotrophic lateral sclerosis . J Neurol Sci 1998;160:Suppl 1:S6-S24.

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Esclerosis Lateral Amiotrófica

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  1. Esclerosis Lateral Amiotrófica 05.dic.2012

  2. Definición

  3. ELAAntecedentes Rowland L, et al. Diagnosis of amyotrophic lateral sclerosis. J NeurolSci 1998;160:Suppl 1:S6-S24. Costa J,et al. Awaji Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis: A Systematic Review. ArchNeurol. 2102.254

  4. Y Patogenia Y Y

  5. Motora Premotora Límbica

  6. Características Fasciculaciones Atrofia Brazis, Paul. Localization in Clinical Neurology, 6th Edition. 2011. Lippincott Williams & Wilkins

  7. Parálisis Pseudobulbar: Articulación Masticación Deglución Incontinencia emocional Características

  8. ELA-Abordaje Diagnóstico:Características a considerar Rowland L, et al. Diagnosis of amyotrophic lateral sclerosis. J NeurolSci 1998;160:Suppl 1:S6-S24. Costa J,et al. Awaji Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis: A Systematic Review. ArchNeurol. 2102.254

  9. ELA-Abordaje Diagnóstico:Auxiliares de Diagnóstico ~10% Proteínas >50mg/dL en 50% Gammapatías 5-10% LCR= estudio de líquido cefaloraquídeo GM1= Anticuerpos contra gangliósido neuronal GM-1 Rowland L, et al. Diagnosis of amyotrophic lateral sclerosis. J NeurolSci 1998;160:Suppl 1:S6-S24. Costa J,et al. Awaji Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis: A Systematic Review. ArchNeurol. 2012.254

  10. ELA-Abordaje Diagnóstico:Auxiliares de Diagnóstico Normal Normal Denervación activa (al menos 3 extremidades) EMG= electromiografía VCC= Velocidades de Conducción eRM= espectroscopia por resonancia magnética MGt= Estimulación Magnética trascraneal Rowland L, et al. Diagnosis of amyotrophic lateral sclerosis. J NeurolSci 1998;160:Suppl 1:S6-S24. Costa J,et al. Awaji Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis: A Systematic Review. ArchNeurol. 2012.254

  11. ELA-Abordaje Diagnóstico:Importancia de Características Clínicas SNMI= Síndrome de neurona motora inferior SNMS= Síndrome de neurona motora superior EMG= electromiografía VCC= Velocidades de Conducción Nerviosa Posible Definitivo Rowland L, et al. Diagnosis of amyotrophic lateral sclerosis. J NeurolSci 1998;160:Suppl 1:S6-S24. Costa J,et al. Awaji Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis: A Systematic Review. ArchNeurol. 2102.254

  12. ELA-Abordaje Diagnóstico:Criterios Diagnósticos de “El Escorial”(1994) revisados (1998) SNMI= Síndrome de neurona motora inferior SNMS= Síndrome de neurona motora superior Rowland L, et al. Diagnosis of amyotrophic lateral sclerosis. J NeurolSci 1998;160:Suppl 1:S6-S24. Costa J,et al. Awaji Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis: A Systematic Review. ArchNeurol. 2102.254

  13. ELA-Abordaje Diagnóstico:Criterios Diagnósticos de “El Escorial”(1994) revisados (1998) SNMI= Síndrome de neurona motora inferior SNMS= Síndrome de neurona motora superior Rowland L, et al. Diagnosis of amyotrophic lateral sclerosis. J NeurolSci 1998;160:Suppl 1:S6-S24. Costa J,et al. Awaji Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis: A Systematic Review. ArchNeurol. 2102.254

  14. Debilidad/Atrofia/Hiper-reflexia/Espasticidad Progresión EMG/VCN/Neuroimagen/Bx/Neuropatrología SNMI en sólo 1 región o SNMS sólo en 1 región SNMI + SNMS 1 región SNMI+SNMS 1 región o SNMS en >1 region SMSI + SNMS >2 regiones SMSI + SNMS 3 regiones Sospecha de ELA ELA Probable ELA Posible ELA Definitiva EMG Denervación en >2 extremidades ELA Apoyada por EMG Rowland L, et al. Diagnosis of amyotrophic lateral sclerosis. J NeurolSci 1998;160:Suppl 1:S6-S24. Costa J,et al. Awaji Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis: A Systematic Review. ArchNeurol. 2102.254

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