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Algorithm of Literature Results

1151 total new citations identified from electronic searches: 207 Bupropion 178 Varenicline 426 NRT 183 Nortriptyline 157 Clonidine. 390 duplicates. Algorithm of Literature Results. Next steps:

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Algorithm of Literature Results

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  1. 1151 total new citations identified from electronic searches: • 207 Bupropion • 178 Varenicline • 426 NRT • 183 Nortriptyline • 157 Clonidine 390 duplicates Algorithm of Literature Results Next steps: 761 potentially relevant reports’ abstracts to be reviewed to determine inclusion/exclusion based on study selection criteria. Next steps: Potentially relevant reports retrieved in full text to determine inclusion/exclusion based on study selection criteria. • 111 relevant reports identified from CADTH: • 25 Bupropion • 10 Varenicline • 76 NRT Next steps: Final selected reports developed into GRADE tables for recommendation development.

  2. Development of Guidelines Needs Assessment: Questions to the Network and GDG to identify clinical questions 1. Topic identification: Smoking Cessation Pharmacotherapy 2. Formation of multidisciplinary guideline development group (GDG) GDG MEETING #1 Oct. 31, 2011 1 hour Overview and Welcome October 3. Define purpose, stakeholders, scope of topic AND Establishment of key clinical questions 4a. Obtain evidence tables and literature from CADTH report 4b. Systematic literature search for studies Guideline Facilitation Process GDG MEETING #2 Nov. 9, 2011 2.5 hours Outcomes and GRADE 5. Filter: Inclusion and Exclusion Criteria 6. Develop sample GRADE Evidence Tables and decide if search/tables meets the needs of the group November Extract Included Evidence into GRADE Evidence Tables GDG MEETING #3 Dec. 6/7, 2011 2 Days Training and Recomm’n Dev’t GROUP MEETING #4 Dec 14, 2011 10am-12 Recomm Dev’tGDG MEETING #5 Jan 9, 2012 10am-12 Recomm Dev’t and approve for external review 7. Circulate and Review GRADE Evidence Tables 8. Drafting recommendations and clinical considerations [GDG] Dec. • 9. Review/Revise recommendations and clinical considerations • 10. External Review Phase 1: Rapid Feedback Targeted individuals and organizations Jan - Feb • 11. External Review Phase 2: Wider distribution to individuals and organizations 12. Revisions/Final Approval (as necessary/appropriate) GROUP MEETING #6 March 5, 2012 10am-12 Approve Guideline as FINAL March 13. Launch of the CAN-ADAPTT Pharmacotherapy Guideline 14. Integrate into existing CAN-ADAPTT implementation strategy

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