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Myelopoiesis is regulated by osteocytes through Gsa-dependent signaling

Myelopoiesis is regulated by osteocytes through Gsa-dependent signaling. Osteoscoop - Issue N°312 – November 2013. Low osteoblast number. Severe osteopenia. Osteocyte-Gs a -/-. Low osteoblast number. Severe osteopenia. Osteocyte-Gs a -/-. Hematopoietic stem cell. Granulocytes.

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Myelopoiesis is regulated by osteocytes through Gsa-dependent signaling

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  1. Myelopoiesis is regulated by osteocytes through Gsa-dependent signaling Osteoscoop - Issue N°312 – November 2013

  2. Low osteoblast number Severe osteopenia Osteocyte-Gsa-/-

  3. Low osteoblast number Severe osteopenia Osteocyte-Gsa-/- Hematopoietic stem cell Granulocytes Monocytes Myeloid stem cell Macrophages

  4. Low osteoblast number Severe osteopenia Osteocyte-Gsa-/- NK Cell T Lymph Lymphoid stem cell B Lymph Hematopoietic stem cell Granulocytes Monocytes Myeloid stem cell Macrophages

  5. Low osteoblast number Severe osteopenia Osteocyte-Gsa-/- NK Cell T Lymph Lymphoid stem cell B Lymph Hematopoietic stem cell + Granulocytes G-CSF Monocytes Myeloid stem cell Macrophages + G-CSF Gsa Osteocyte

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