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Advances in Eosinophilic Gastrointestinal Diseases: Insights from the 2007 ICD-9 Coordination Committee Meeting

Learn about the impact of EGIDs on patients' quality of life, the increasing incidence in both adults and children, challenges in pathogenesis understanding, and current treatment approaches at the 2007 committee meeting in Baltimore.

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Advances in Eosinophilic Gastrointestinal Diseases: Insights from the 2007 ICD-9 Coordination Committee Meeting

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  1. Eosinophilic Gastrointestinal Diseases ICD-9 Coordination Committee Meeting Baltimore, MD September 28. 2007 Glenn T. Furuta, MD University of Colorado Medical School The Children’s Hospital, Denver

  2. Four points • Eosinophilic Gastrointestinal Diseases (EGIDs) impact patient’s quality of life. • Adults and children are affected by these chronic diseases with increasing frequency. • Pathogenesis suggest role for allergy but still not certain; treatment limited to corticosteroids and dietary elimination • Currently, borrowing from other diseases.

  3. “ EGIDs impact patient’s quality of life” Definition- Consensus Statement 2007 • Broad range of symptoms-often confused with other diseases • Histology demonstrates increased eosinophils in intestinal tissue

  4. “ EGIDs impact patient’s quality of life” • Esophagitis- ? • Unresponsive GERD • Feeding problems / slow growth • Dysphagia and food impaction • Gastritis-? • Abdominal pain, bleeding, vomiting • Gastroenteritis and colitis-? • As above • Diarrhea • Swelling • Missed school and Work absenteeism

  5. Eosinophilic Esophagitis“530.13”

  6. Eosinophilic Gastritis“535.41” Eosinophilic Gastroenteritis / Enteritis“558.41”

  7. Eosinophilic Colitis“558.42”

  8. “Adults and children are increasingly affected” • Recent studies identify both rise in incidence and recognition • Familial clustering • Genetic markers

  9. EGIDs publications(1978-2007) Publications Year

  10. “Pathogenesis suggest allergic role; Treatment limited to corticosteroids and dietary elimination” • IgE vs. Non IgE mediated • Long term eosinophilic inflammation associated with fibrosis • Food elimination and / or corticosteroids leads to improvement in many patients.

  11. Pre-endoscopy Post-endoscopy Esophageal Stricture Small caliber esophagus

  12. “Borrowing from other diseases” • Other eosinophilia / esophagitis 288.3 / 530.1 • Allergic gastroenteritis 558.3

  13. “Borrowing from other diseases” • Track-epidemiology • NIH-funding for research • Therapeutic interventions

  14. Four points • Eosinophilic Gastrointestinal Diseases (EGIDs) impact patient’s quality of life. • Adults and children are affected by these chronic diseases with increasing frequency. • Pathogenesis suggest role for allergy but still not certain; treatment limited to corticosteroids and dietary elimination • Currently, borrowing from other diseases.

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