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Understanding Nitric Oxide and Vascular Smooth Muscle Regulation

Explore the intricate mechanisms of NO synthesis, cGMP signaling, and vasodilation in vascular tissues. Learn how neural and intrinsic factors influence flow regulation in endothelium and VSM cells.

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Understanding Nitric Oxide and Vascular Smooth Muscle Regulation

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  1. K 305 2 June 03

  2. Regulation of Flow (Q) • Vascular Smooth Muscle Cells • Endothelium • Neural • Other Tissues • Intrinsic Factors

  3. Regulation of Flow (Q) • Vascular Smooth Muscle Cells • Endothelium • Neural • Other Tissues • Intrinsic Factors

  4. Regulation of Flow (Q) • Vascular Smooth Muscle Cells • Endothelium • Nitric Oxide • Endothelin • EDRF

  5. Nitric Oxide • NO (EDRF) synthesized in endothelial cells by NOS • NOS stimulated by elevated [Ca2+]i • NOS converts arginine to NO • NO freely permeates out of endothelial cell into VSM • In VSM stimulates guanylyl cyclase increasing cGMP • cGMP activates PKG which stimulates: • SERCA (through phospholamban) and PMCA • Reduces [Ca2+]i - relaxation - VASODILATION • vasodilator drugs nitroglycerin and nitroprusside

  6. Nitric Oxide – Ca2+ independent • Activates GC in VSM to stimulate PKG • PKG prevents Rho A from being activated • Prevents inhibition of MLC Phosphatase • Dephosporylates MLK • Induces relaxation in VSM - VASODILATION

  7. Regulation of Flow (Q) • Vascular Smooth Muscle Cells • Endothelium • Nitric Oxide • Endothelin • EDRF

  8. Regulation of Flow (Q) • Vascular Smooth Muscle Cells • Endothelium • Neural • Other Tissues • Intrinsic Factors

  9. Regulation of Flow (Q) • Vascular Smooth Muscle Cells • Neural • NA – a adrenergic receptor • NA – b adrenergic receptor • ACh – muscarinic receptor

  10. Regulation of Flow (Q) • Vascular Smooth Muscle Cells • Endothelium • Neural • Other Tissues • Intrinsic Factors

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