SARC Career Development Award Program

1. SARC Career Development Award Program Richard Gorlick, MD Lee Helman, MD

2. SARC Career Development Award • Fund established 2007 • Initial award granted 2009 • Incorporated into the SARC sarcoma SPORE in 2013 • Purpose • To help prepare and support scientists working in sarcoma as they begin their careers as independent researchers

3. Committee R. Gorlick, Co-Chair L. Helman, Co-Chair J. Crowley J. Fletcher M. Thornton F. Hornicek D. Lev C. Mackall M. van de Rijn S. Schuetze L. Schwartz SARC Career Development Award

4. SARC Career Development Program 2014 • SARC Sarcoma SPORE Career Development Award • Requires awardees to be US citizens • SARC is interested in continued support of researchers internationally • Two funding opportunities • US based researcher • International researcher

5. SARC SPORE CDA • Criteria • Final year of clinical fellowship or postdoctoral fellowship, or within five years of first faculty appointment • Demonstrated track record of interest and productivity in research relevant to sarcoma • US citizen • Funding Level • $100,000 per year, for up to two years

6. International CDA • Criteria • Final year of clinical fellowship or postdoctoral fellowship, or within five years of first faculty appointment • Demonstrated track record of interest and productivity in research relevant to sarcoma • Citizenship outside US • Funding Level • $100,000 per year, for up to two years

7. Application Process • Two step process • Letter of Intent • Full application • Letter of intent due • January 3, 2014 • Contact SARC with any questions • sarc@sarctrials.org

8. 2009 Career Development Award Recipients Sandra Strauss, MD, PhD University College London Joseph Ludwig, MD University of Texas, MD Anderson Cancer Center • Anchorage-independent conditions as a model for micrometastatic disease in osteosarcoma • Targeted therapy of Ewing’s Sarcoma via IGF-1R signaling cascade

9. 2010 Career Development Award Recipients Patrick J. Grohar, MD, PhD Fellow, National Cancer Institute Joshua D. Schiffman, MD Assistant Professor, University of Utah • Novel genomic approach to risk-stratify and identify relapse-associated copy number alterations in Ewing’s sarcoma • Development of a Small Molecule Therapy Targeting EWS-FLI1

10. 2011 Career Development Award Recipients Keila Enitt Torres, MD, PhD University of Texas, MD Anderson Cancer Center Seth M. Pollack, MD University of Washington/Fred Hutchinson Cancer Research Center • The role of the P13K/AKT/mTOR pathway in radiation associated sarcoma (RAS) • Adoptive T-cell therapy for patients with metastatic sarcoma

11. 2012 Career Development Award Recipients AdriánMariño-Enríquez, MD Harvard Medical School, Brigham and Women’s Hospital, Department of Pathology Brian A. Van Tine, MD, PhD Washington University, Division of Medical Oncology Director, and Assistant Professor, Division of Medical Oncology • Genome-wide functional characterization of GIST: Strategies to maximize kinase-inhibitor response • Exploiting ArgininosuccinateSynthase 1 Deficiency in Sarcoma.

12. 2013 Career Development Award Recipients CigallKadoch, PhD Broad Institute Simone Hettmer, MD, Dana Farber Cancer Institute John Shern, MD National Cancer Institute • Identifying novel therapies in pediatric RMS using high-throughput screening for inhibitors of the PAX3-FOX01 Oncogenic transcription factor • Evaluation of the contributions of candidate RMS-relevant genes/pathways in RMS malignancy • Reversing the roles of misdirected chromatin remodeling in human synovial sarcoma

13. 2014 Career Development Application Key Dates • January 3, 2014 • Letter of Intent • March 31, 2014 • Submission of Grant Proposal • July 1, 2013 • Funding Period Begins