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Audiogram-Based Risk Assessment for Ototoxicity in Cisplatin Treatment

This study presents a method for pretreatment risk assessment of auditory damage in patients undergoing cisplatin therapy. Using a series of predictive audiograms derived from baseline data, the effectiveness of planned cisplatin dosing regimens is evaluated against actual audiometric thresholds. The analysis, which includes conventional frequency thresholds, showcases an overall accuracy of 4.9 to 8.0 dB prediction error. Insights from the research support the development of a comprehensive monitoring program for ototoxicity in VA healthcare settings, with implications for patient management.

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Audiogram-Based Risk Assessment for Ototoxicity in Cisplatin Treatment

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  1. Figure 2. Pretreatment risk assessment audiograms using threshold information from case study 1. Series of prediction audiograms were generated using planned cisplatin dosing regimen (dashed lines) and patient’s actual baseline audiogram (solid line) in decibels hearing level (dB HL) shown as function of test frequency. Gray shading indicates “speech banana” with phonemes. This model of conventional frequency thresholds yielded overall accuracy of 4.9 to 8.0 dB prediction error. Konrad-Martin D, Reavis KM, McMillan G, Helt WJ, Dille M. Proposed comprehensive ototoxicity monitoring program for VA healthcare (COMP-VA). J Rehabil Res Dev. 2014;51(1):81–100. http://dx.doi.org/10.1682/JRRD.2013.04.0092

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