Psychopharmacology by Sue Henderson. Terminology. National Health Survey 04-05. Decline in hospital stay. Key points about drugs:. Drugs alter or mimic body functions (but do not create new functions) Drugs have multiple actions (which may or may not be desired).
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Drugs alter or mimic body functions
(but do not create new functions)
Drugs have multiple actions
(which may or may not be desired).
Most psychotropic drugs interact with the body via receptors.
2. “Gee it’s wonderful. It’s simple & cures magically”
1. “Another one of his fool ideas”
4. Used carefully in selected cases it is the best therapy for “X” disease.
3. Death from “X”. “It’s a poison! I wouldn’t give it to a dog!”
Absorption: The rate at which a drug gets out of the G.I. tract & into the blood stream.
Distribution: process of drug molecules leaving the blood stream to reach tissues & organs.
Capillary wallBlood Brain Barrier BBB
Metabolism: Detoxification or breakdown. Enzymes (Cytochrome P450) in liver cells transform drug from fat soluble to water soluble.
Elimination: removal of drug from body. Most via kidney’s, lungs & G.I. Tract (small amounts)
Drug receptor interaction: drug concentrated at the site of action.
Effect (body responses): Therapeutic effects, intoxication & side effects.
The effect will vary depending on age, gender & health of person, plus the route, frequency of use, duration of use and the environment in which the drug is consumed.
Presynaptic storage vesiclesNormal neurotransmission
NoradrenalineAll 6 major neurotransmitters have been shown to influence each other’s function in the brain.