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Overcoming Low-Yield Challenges in Complex Multi-Step Reactions

In this insightful case study, Aurigene shares how its team tackled a multi-step, low-yield synthetic route involving protection-deprotection sequences, labile intermediates, and significant by-product formation. Leveraging strategic route scouting, Aurigene pinpointed a streamlined synthetic pathway that reduced the process to just three chemical conversionsu2014significantly shortening cycle time for the novel chemical entity (NCE).<br>https://www.aurigeneservices.com/case-studies/low-yield-challenges-atypical-reaction

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Overcoming Low-Yield Challenges in Complex Multi-Step Reactions

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  1. Case Study Low yield challenges of atypical reaction 1

  2. Project challenge: Seven stage sequence involving protection- deprotection sequence, labile intermediates and signicant by-product formation with low yield. Solution design: Salient features of the approach: ●Route scouting to come up with a new route that furnished the NCE in three chemical conversions, thus reducing the cycle time of development of NCE Route scouting to come up with a new route that furnished the NCE in three chemical conversions ●Identication of suitable protecting groups and deprotecting reagents and reaction conditions to optimize the yield ●Route developed was implemented in manufacturing plant and process validation performed ●Effective purication techniques including crystallization resulted in control of unknown impurities and generated quality product, meeting ICH specications Conclusion: This case study exemplies the technical abilities of our team in route scouting and developing a process that can be implemented on scale and creating value to the customer in terms of cost and time. 2

  3. Thank You For more information please visit https:/ /www.aurigeneservices.com/ To place an inquiry please visit https:/ /www.aurigeneservices.com/form/contact Mail us at contactapsl@aurigeneservices.com 3

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